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Frailty in kidney transplant candidates: new therapeutic strategies to intervene.
Curr Opin Organ Transplant
January 2025
Department of Kinesiology and Health Sciences.
Purpose Of Review: Patients that present with a physical frail phenotype have a higher risk of poor kidney transplant outcomes and are therefore less likely to be wait listed for a transplant. The physical frailty phonotype is more prevalent in older adults >65years with chronic and end stage kidney disease, thus partly contributing to inequitable access to transplant. Frailty can potentially be reversed by prehabilitation.
View Article and Find Full Text PDFTotal shoulder arthroplasty in a patient with osteopetrosis: A case report.
Radiol Case Rep
March 2025
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Osteopetrosis is a rare genetic disorder that leads to increased bone density and fragility due to dysfunctional osteoclasts, which can result in narrowed bone marrow spaces, hardened cartilage, and brittle bones. This condition frequently coexists with osteoarthritis among affected individuals. When osteoarthritis results in significant pain and impairs function, surgical interventions such as total joint arthroplasty may be recommended, although these procedures come with a unique set of surgical and recovery-related hurdles.
View Article and Find Full Text PDFThe impact of preexisting psychiatric disorders on patient outcomes following primary total shoulder arthroplasty: A systematic review and quantitative synthesis.
Shoulder Elbow
January 2025
Sunnybrook Orthopaedic Upper Limb (SOUL), Sunnybrook Health Sciences Centre, Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Purpose: To summarize complication rates, reoperation rates, length-of-stay (LOS), patient-reported outcome measures (PROMs), and range of motion following total shoulder arthroplasty (TSA) in patients with preexisting psychiatric disorders (PDs) compared to controls.
Methods: Three databases (MEDLINE, PubMed, and EMBASE) were searched from inception to 4 March 2024 to identify studies comparing outcomes between patients undergoing anatomic (aTSA) or reverse TSA (rTSA) with or without a preexisting psychiatric condition. The authors adhered to the preferred reporting items for systematic reviews and meta-analyses and revised assessment of multiple systematic review guidelines.
Immune infiltration landscape and potential drug-targeted implications for hepatocellular carcinoma with 'progression/hyper-progression' recurrence.
Ann Med
December 2025
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, China.
Background And Aims: Hepatocellular carcinoma (HCC) recurrence was previously characterized into four types, and patients with progression/hyper-progression recurrence (type III-IV) have an extremely poor prognosis. However, the immune background of resectable HCC, particularly in patients who experience recurrence, remains underexplored. Therefore, this study aimed to describe the immune landscape of resectable HCC, especially postoperative type III-IV recurrent HCC, and explore potential immune-targeted anti-relapse strategies for treated populations.
View Article and Find Full Text PDF[Application of ambulatory surgery management mode in total laparoscopic ileostomy reversal surgery].
Zhonghua Yi Xue Za Zhi
February 2025
Department of Gastrointestinal Oncology Surgery, National Cancer Regional Medical Center, Cancer Hospital Chinese Academy of Medical Sciences Liaoning Hospital, the First Hospital of China Medical University, Shenyang 110001, China Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
To explore the safety of application of ambulatory surgery management mode in total laparoscopic ileostomy reversal surgery. A retrospective analysis of clinical data was conducted on patients who had undergone total laparoscopic ileostomy reversal surgery at the First Affiliated Hospital of China Medical University from May 1, 2023, to March 31, 2024. A total of 34 patients were included in the study, comprising 22 males and 12 females, with the age of (60.
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