Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465326 | PMC |
| http://dx.doi.org/10.1097/00000658-195608000-00009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Surrogate End Points for Overall Survival in Neoadjuvant Randomized Clinical Trials for Early Breast Cancer.
J Clin Oncol
January 2025
German Breast Group, Neu-Isenburg, Germany.
Purpose: To assess trial-level surrogacy value for overall survival (OS) of the pathologic complete response (pCR) and invasive disease-free survival (iDFS) in randomized clinical trials (RCTs) for early breast cancer (BC).
Methods: Individual patient data of neoadjuvant RCTs with available data on pCR, iDFS, and OS were included in the analysis. We used the coefficient of determination from weighted linear regression models to quantify the association between treatment effects on OS and on the surrogate end points.
Preoperative Resilience as a Predictor of Postoperative Regret and Patient-Reported Outcomes in Total Knee Arthroplasty.
J Am Acad Orthop Surg
January 2025
From the Department of Orthopaedic Surgery, Kaiser Permanente San Diego Medical Center, San Diego, CA (Horan), the Department of Orthopaedic Surgery, Summit Orthopedics, Eagan, MN (Baer), Shiley Center for Orthopaedic Research and Education (SCORE) at Scripps Clinic, La Jolla, CA (Shah), Georgetown University School of Medicine, Washington, DC (Shah), and the Department of Orthopaedic Surgery, Scripps Clinic, La Jolla, CA (Wilde, Copp, and Bugbee).
Background: Total knee arthroplasty (TKA) is a well-established treatment option for advanced knee osteoarthritis, yet some patients remain unsatisfied after surgery. Evaluation of various psychosocial parameters may improve patient optimization and outcomes. The primary aim was to assess whether preoperative resilience remained stable and influenced decision regret postoperatively while the secondary aim was to evaluate its correlation with joint-specific and global health patient-reported outcome measures.
View Article and Find Full Text PDFA high-resolution view of RNA endonuclease cleavage in Bacillus subtilis.
Nucleic Acids Res
January 2025
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
RNA endonucleases are the rate-limiting initiator of decay for many bacterial mRNAs. However, the positions of cleavage and their sequence determinants remain elusive even for the well-studied Bacillus subtilis. Here we present two complementary approaches-transcriptome-wide mapping of endoribonucleolytic activity and deep mutational scanning of RNA cleavage sites-that reveal distinct rules governing the specificity among B.
View Article and Find Full Text PDFEffect of Frailty on Postoperative Outcomes Following Major Abdominal Surgeries: A Prospective Observational Study.
Indian J Crit Care Med
November 2024
Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Background: Frailty poses unique challenges for patients undergoing major cancer surgeries due to their extreme vulnerability to physiological stressors and can be an important factor in determining postoperative outcomes.
Aims And Objective: The objective of the study was to determine the incidence of frailty in patients undergoing major abdominal cancer surgeries and identify the risk factors predicting poor outcomes.
Materials And Methods: This was a prospective observational study conducted following institutional ethics approval and CTRI registration.
Coalescence of multiple topological orders in quasi-one-dimensional bismuth halide chains.
Nat Commun
January 2025
School of Physics, Beihang University, Haidian District, Beijing, China.
Topology is being widely adopted to understand and to categorize quantum matter in modern physics. The nexus of topology orders, which engenders distinct quantum phases with benefits to both fundamental research and practical applications for future quantum devices, can be driven by topological phase transition through modulating intrinsic or extrinsic ordering parameters. The conjoined topology, however, is still elusive in experiments due to the lack of suitable material platforms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!