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Factors contributing to helminth prevalence after repeated mass administration of medicines in Anambra State, Nigeria.
Sci Rep
January 2025
Neglected Tropical Diseases Unit, Anambra State Ministry of Health, Awka, Nigeria.
Over the past decade, Mass Administration of Medicines (MAM) has been a key strategy for controlling schistosomiasis and soil-transmitted helminthiasis (STHs) in Anambra State, Nigeria. This longitudinal study, conducted from 2017 to 2019, evaluated the impact of interventions for controlling schistosomiasis (SCH) and STHs in recipient communities. A total of 1,046 pupils aged 5 to 16 years were enrolled, with Kato-Katz and urine filtration methods used for faecal and urine sample analysis.
View Article and Find Full Text PDFMating system of a vector of .
Curr Res Parasitol Vector Borne Dis
January 2025
Western University of Health Sciences, 200 Mullins Dr, Lebanon, OR, 97355, USA.
snails are intermediate hosts for schistosome parasites, which cause morbidity and mortality in humans worldwide. We aimed to determine the mating system of , a hermaphroditic vector of schistosomiasis in the African Great Lakes, with the goal of informing the design of genetic studies such as linkage mapping to improve genome assembly and genetic association studies to identify snail resistance genes. To determine the relative rates of outcrossing selfing, we assayed the progeny of experimental crosses of snails in the laboratory using a PCR and restriction enzyme digest to determine snail genotype and parentage.
View Article and Find Full Text PDFThe spectrum and outcome of metastatic hepatocellular carcinoma in a South African patient cohort.
HPB (Oxford)
January 2025
Surgical Gastroenterology Unit, Division of General Surgery, University of Cape Town Faculty of Health Sciences and Groote Schuur Hospital, Cape Town, South Africa. Electronic address:
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally, particularly in developing countries in Southeast Asia and sub-Saharan Africa (SSA), where chronic hepatitis B virus (HBV) dominates as a major aetiological factor.
Methods: We conducted a retrospective cohort study to quantify the metastatic profile of HCC in a South African patient population managed at a tertiary centre. Demographic, clinical and treatment data were extracted from an institutional registry.
Evaluating stakeholder coordination and partnerships for NTD elimination in Taraba state, Nigeria: a multi-level analysis.
BMC Infect Dis
January 2025
Pan-African Community Initiative on Education and Health (PACIEH), Ekulu West GRA, No. 8 Somto Anugwom Close, Enugu, Enugu State, 400102, Nigeria.
Introduction: Nigeria has a significant burden of NTDs with more than 120 million people at risk of the dominant NTDs namely Lymphatic Filariasis, Onchocerciasis, and Schistosomiasis. Control efforts have involved the four levels of governance with programs focused on vector control, preventive chemotherapy, water, sanitation and health education. However, the coordination across these levels and with multiple stakeholders remains unclear especially in states like Taraba that have received significant funding from local non-governmental organisations.
View Article and Find Full Text PDFMigrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice.
Stem Cell Res Ther
January 2025
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, Jiangsu, P. R. China.
Background: Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation in experimental allergic diseases, representing a potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated in migrating cells and facilitate intercellular communication.
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