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Characterization of non-typhoidal Salmonella reveals the highly prevalent mcr-1-positive S. 1,4,[5],12:i:- within eggs are derived from chickens.
Int J Food Microbiol
December 2024
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China. Electronic address:
Salmonella is one of the most common foodborne pathogens. Antimicrobial-resistant Salmonella isolates, especially those resistant to colistin, pose a significant threat to public health worldwide. However, data about the prevalence of mcr-positive Salmonella in animals was few and the dissemination of mcr-positive Salmonella from animals to food, especially eggs, has not been fully addressed.
View Article and Find Full Text PDFEvaluation of a point-of-care immunochromatographic assay for enteric fever in Dhaka, Bangladesh: a prospective diagnostic accuracy study.
Lancet Microbe
December 2024
Massachusetts General Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:
Background: There is a shortage of rapid, accurate, and low-cost assays for diagnosing enteric fever. The dual-path platform for typhoid (DPPT) assay had high accuracy in retrospective studies with banked plasma samples. We aimed to evaluate the diagnostic accuracy of the DPPT assay in a prospective study using fingerstick capillary blood.
View Article and Find Full Text PDFDesign of a Glycoconjugate Vaccine Against Paratyphi A.
Vaccines (Basel)
November 2024
GSK Vaccines Institute for Global Health (GVGH), 53100 Siena, Italy.
Background/objectives: Typhoid and paratyphoid fever together are responsible for millions of cases and thousands of deaths per year, most of which occur in children in South and Southeast Asia. While typhoid conjugate vaccines (TCVs) are licensed, no vaccines are currently available against Paratyphi A. Here we describe the design of a Paratyphi A conjugate.
View Article and Find Full Text PDFGenomic characteristics of serovar Blockley.
Microbiol Spectr
November 2024
Department of Bacteriology I, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Article Synopsis
- * This study analyzed 264 Blockley isolates from different regions, identifying 10 distinct genetic clusters which led to the classification into two lineages—R and S—each with unique antimicrobial resistance profiles.
- * Notably, lineage R, found mainly in Asia and Africa, contained strains with azithromycin resistance, while lineage S, primarily in Europe and the Americas, lacked this resistance, indicating a significant need for ongoing monitoring of these pathogens.
Comparative genomic analysis provides new insights into non-typhoidal Salmonella population structure in Peru.
Sci Rep
November 2024
Laboratorio de Referencia Nacional de Bacteriología Clínica, Instituto Nacional de Salud, Lima, Peru.
Article Synopsis
- Non-typhoidal Salmonella (NTS) is a major cause of foodborne outbreaks globally, especially in countries like Peru, necessitating an analysis of its circulating serotypes.
- Researchers studied the genomes of 1122 NTS strains from 1998 to 2018, identifying 40 different Sequence Types (STs), with ST-32 and ST-11 being the most prevalent.
- The study revealed that strains within the same ST are genetically similar and that certain virulence factors and drug resistance are strongly associated with these common STs, indicating their adaptation in the region.
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