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Route of Infection Strongly Impacts the Host-Pathogen Relationship.
Front Immunol
October 2020
Unité de Recherche en Biologie des Microorganismes, Laboratoire d'Immunologie et de Microbiologie, NARILIS, Université de Namur, Namur, Belgium.
Live attenuated vaccines play a key role in the control of many human and animal pathogens. Their rational development is usually helped by identification of the reservoir of infection, the lymphoid subpopulations associated with protective immunity as well as the virulence genes involved in pathogen persistence. Here, we compared the course of infection in C57BL/6 mice infected via intraperitoneal (i.
View Article and Find Full Text PDFThe prevalence of brucellosis and bovine tuberculosis in ruminants in Sidi Kacem Province, Morocco.
PLoS One
February 2019
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Bovine tuberculosis (BTB) and brucellosis are major endemic zoonoses in ruminants in Morocco that impact on both animal and human health. This study presents an assessment of the epidemiological and socioeconomic burden of bacterial zoonoses in Sidi Kacem Province in Northern Morocco from a cross-sectional survey of 125 cattle and/or small ruminant-owning households. In total, 1082 sheep and goats were examined from 81 households.
View Article and Find Full Text PDFImmunotoxic effect of thiamethoxam in immunized mice with cultural filtrate antigen.
Vet World
December 2016
Ministry of High Education and Scientific Research, Baghdad, Iraq; Department of Internal and Preventive Veterinary Medicine, University of Baghdad, Baghdad, Iraq.
Aim: This study was planned for determination the toxic effect of thiamethoxam (TMX) in immunized mice with culture filtrate antigen (CFBAgs) (as a vaccine) and its role of TMX on decrease activity of antigen on eliciting of humoral and cellular immunity.
Materials And Methods: To achieve these goals 60 female mice were used, 7-8 weeks age, they were divided equally into three groups (20 in each group) and treated as follows: 1 group: Mice were immunized with CFBAgs intraperitoneally in two doses, 2 weeks intervals with (protein concentration 2 mg\ml), 2 group: Mice immunized as in the 1 group and was administrated orally with 1/10 lethal dose 50% of TMX (83.7 mg/kg B.
COX-2 Inhibition Reduces Bacterial Burden in Draining Lymph Nodes.
Front Microbiol
December 2016
Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy Marseille, France.
is a Gram-negative facultative intracellular bacterium responsible for a chronic disease known as brucellosis, the most widespread re-emerging zoonosis worldwide. Establishment of a Th1-mediated immune response characterized by the production of IL-12 and IFNγ is essential to control the disease. Leukotrienes derived from arachidonic acid (AA) metabolism are known to negatively regulate a protective Th1 immune response against bacterial infections.
View Article and Find Full Text PDFFirst results on small ruminant brucellosis and tuberculosis and caprine arthritis-encephalitis in El Salvador.
Trop Anim Health Prod
June 2016
Institute of Food Hygiene, Center of Veterinary Public Health, Faculty of Veterinary Medicine, Universität Leipzig, An den Tierkliniken 1, 04103, Leipzig, Germany.
This paper reports a first-time study performed in El Salvador on the presence or absence of antibodies to three important animal diseases in small ruminants. The work was conducted in the west and central departments of the country, selecting 42 and 43 cantons with an existing sheep and goat population, respectively. Serum samples were collected from 396 sheep and 335 goats and tested for seropositivity to Brucella (B.
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