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Antimicrobial agents in agricultural fertilizers produced from sewage sludge - A cause for concern?
Sci Total Environ
January 2025
University of Bath, Department of Chemistry, Bath BA2 7AY, United Kingdom; Centre of Excellence in Water-Based Early Warning Systems for Health Protection, University of Bath, Bath BA25RX, United Kingdom.
The production of organic-mineral fertilizers from sewage sludge is one of the ecological options in their management. Though, pharmaceuticals and their derivatives, which accumulate in the sludge, could be a problem due to their impacts on the environment. This manuscript aimed at better understanding of risks posed by antimicrobial agents (AAs) in sludge-based fertilizers.
View Article and Find Full Text PDFInvestigating the Effect of Capric Acid on Antibiotic-Induced Autism-Like Behavior in Rodents.
Dev Neurobiol
January 2025
Neuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.
Article Synopsis
- The gut-brain axis is crucial in neurodevelopmental diseases, with early antibiotic use linked to autism through gut microbiota changes.
- Capric acid (CA) was studied for its potential neuroprotective effects in rodents with autism-like behaviors induced by penicillin V, highlighting the impact of gut dysbiosis.
- Results showed that CA treatment improved behavioral and biochemical changes related to autism, suggesting its potential as a treatment option for managing autism linked to gut dysbiosis.
Ionic Crosslinking of Linear Polyethyleneimine Hydrogels with Tripolyphosphate.
Gels
December 2024
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Ciencias Químicas, Ciudad Autónoma de Buenos Aires 1113, Argentina.
In this work, the mechanical properties of hydrogels based on linear polyethyleneimine (PEI) chemically crosslinked with ethyleneglycoldiglycidyl ether (EGDE) were improved by the ionic crosslinking with sodium tripolyphosphate (TPP). To this end, the quaternization of the nitrogen atoms present in the PEI structure was conducted to render a network with a permanent positive charge to interact with the negative charges of TPP. The co-crosslinking process was studied by H high-resolution magic angle spinning (H HRMAS) NMR and X-ray photoelectron spectroscopy (XPS) in combination with organic elemental analysis and inductively coupled plasma mass spectrometry (ICP-MS).
View Article and Find Full Text PDFWeekly dihydroartemisinin-piperaquine versus monthly sulfadoxine-pyrimethamine for malaria chemoprevention in children with sickle cell anaemia in Uganda and Malawi (CHEMCHA): a randomised, double-blind, placebo-controlled trial.
Lancet Infect Dis
December 2024
Training and Research Unit of Excellence, Blantyre, Malawi; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Background: In many sub-Saharan African countries, it is recommended that children with sickle cell anaemia receive malaria chemoprevention with monthly sulfadoxine-pyrimethamine or daily proguanil as the standard of care. However, the efficacy of these interventions is compromised by high-grade antifolate resistance of Plasmodium falciparum and poor adherence. We aimed to compare the efficacy of weekly dihydroartemisinin-piperaquine and monthly sulfadoxine-pyrimethamine for the prevention of clinical malaria in children with sickle cell anaemia in areas with high-grade sulfadoxine-pyrimethamine resistance of P falciparum in Uganda and Malawi.
View Article and Find Full Text PDFFunctional and molecular characterization of millet associated probiotic bacteria.
BMC Microbiol
November 2024
Department of Food and Nutrition, Kyung Hee University, Seoul, 02447, Republic of Korea.
The lactic acid bacteria are one of the sustainable ways of food production. As the native lactic acid bacteria (LAB) easily manipulate the substrate, helps in production of health essential probiotics with enhancing the bioavailability of the substrate. Here also, in present study, the native LAB isolates isolated from the millets and characterize them for the functional analysis for the human health association.
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