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Article Synopsis
  • Rowell Syndrome is a rare condition that combines features of erythema exudativum multiforme (EEM) and lupus erythematosus (LE).
  • The new diagnostic criteria include three major criteria (different types of LE, EEM-like skin lesions, and a specific antibody pattern) and several minor criteria (chilblains and certain positive antibody tests).
  • Treatment options are similar to those for EEM and LE, often showing positive results with medications like oral cortisone and azathioprine, and the presented case showed good improvement with topical treatments following a herpes infection and sun exposure.
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There is a liver damage in a serious side effect of regorafenib. Case 1 was a 54-year-old woman, and she had an operation of rectal cancer and metastasized to multiple organs afterwards and started regorafenib as third-line. Erythema exudativum multiform developed on the 8th day after a start and regorafenib was canceled once and reduced on the 21st day when a skin symptom was relieved and restarted.

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Q fever is a rare worldwide zoonosis, caused by the rickettsial bacteria Coxiella burnetii. There are many clinical manifestations of infection, but the most common ones are fever, atypical pneumonia, and/or liver disease. Cutaneous involvement, however, is not a typical feature of Q fever, but it is nevertheless present in up to 20% of cases.

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RS3PE syndrome developing during the course of probable toxic shock syndrome: a case report.

BMC Infect Dis

April 2018

Department of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan.

Background: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare syndrome characterized by "remitting," "seronegative" (namely rheumatoid factor-negative), and "symmetrical" synovitis with pitting edema on the dorsum of the hands and feet. Recently, there have been reports that serum vascular endothelial growth factor (VEGF) is elevated in this condition.

Case Presentation: An 85-year-old man visited our department with a rash that had appeared 2 days earlier and a fever that had developed on the day of his visit.

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