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Maternal consumption of fish oil protected breast-fed piglets against lipopolysaccharide-induced damage through reshaping of intestinal fatty acids profile.
Front Vet Sci
June 2024
Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
It has been well documented that n-3 polyunsaturated fatty acids (n-3 PUFA) can alleviate inflammation caused by () lipopolysaccharides (LPS), the etiologic agents that causing yellow or white dysentery in young pigs. However, it remains unclear whether the increase in n-3 PUFA availability could enhance the ability of nursery pigs to resist invasion by . LPS.
View Article and Find Full Text PDFDevelopment of a visual Adhesion/Invasion Inhibition Assay to assess the functionality of -specific antibodies.
Front Immunol
April 2024
Monoclonal Antibody Discovery Laboratory, Fondazione Toscana Life Sciences, Siena, Italy.
Introduction: is the etiologic agent of a bacillary dysentery known as shigellosis, which causes millions of infections and thousands of deaths worldwide each year due to 's unique lifestyle within intestinal epithelial cells. Cell adhesion/invasion assays have been extensively used not only to identify targets mediating host-pathogen interaction, but also to evaluate the ability of -specific antibodies to reduce virulence. However, these assays are time-consuming and labor-intensive and fail to assess differences at the single-cell level.
View Article and Find Full Text PDFMolecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus in Xinjiang, China, from 2020 to 2022.
Arch Virol
April 2024
College of Animal Science and Technology, Shihezi University, Shihezi, 832003, Xinjiang, China.
In recent years, the pig industry in Xinjiang, China, has been severely impacted by outbreaks of porcine epidemic diarrhea (PED), despite vaccination efforts. In this study, we investigated the genetic characteristics of currently prevalent porcine epidemic diarrhea virus (PEDV) strains in the region. We collected 548 samples from animals with suspected PED on large-scale pig farms in Xinjiang.
View Article and Find Full Text PDFLower gut bleeding is an alarming sign among caregivers. Determining the etiology is of utmost importance for further management. This is the first study conducted in northernmost India.
View Article and Find Full Text PDFDiffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri.
Sci Rep
August 2023
Institute Pasteur Italia, Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, p.le Aldo Moro 5, 00185, Rome, Italy.
Shigella, the aetiological agent of human bacillary dysentery, controls the expression of its virulence determinants through an environmentally stimulated cascade of transcriptional activators. VirF is the leading activator and is essential for proper virulence expression. In this work, we report on in vitro and in vivo experiments showing that two autoinducers of the DSF family, XcDSF and BDSF interact with the jelly roll module of VirF causing its inhibition and affecting the expression of the entire virulence system of Shigella, including its ability to invade epithelial cells.
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