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Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy.
Noncoding RNA
December 2024
Department of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, Russia.
Pre-eclampsia (PE) is a serious condition affecting 2-8% of pregnancies worldwide, leading to high maternal and fetal morbidity and mortality. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as potential biomarkers for various pregnancy-related pathologies, including PE. MiRNAs in plasma and serum have been extensively studied, but urinary miRNAs remain underexplored, especially during early pregnancy.
View Article and Find Full Text PDFEvaluation of the Human Placental Microbiota in Early- and Late-Onset Pre-Eclampsia.
High Blood Press Cardiovasc Prev
November 2024
Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Introduction: Despite many decades of research, the exact etiology of pre-eclampsia (PE) remains unknown. Several etiopathologies have been suggested, including the role of the placental microbiota. However, the existence of placental microbiota and its possible contribution to pregnancy complications, particularly PE has remained controversial.
View Article and Find Full Text PDFDevelopment of non-invasive biomarkers for pre-eclampsia through data-driven cardiovascular network models.
Sci Rep
October 2024
Biomedical Engineering Simulation and Testing Lab, Department of Biomedical Engineering, Faculty of Science and Engineering, Swansea University, Swansea, SA1 8EN, UK.
Computational models can be at the basis of new powerful technologies for studying and classifying disorders like pre-eclampsia, where it is difficult to distinguish pre-eclamptic patients from non-pre-eclamptic based on pressure when patients have a track record of hypertension. Computational models now enable a detailed analysis of how pregnancy affects the cardiovascular system. Therefore, new non-invasive biomarkers were developed that can aid the classification of pre-eclampsia through the integration of six different measured non-invasive cardiovascular signals.
View Article and Find Full Text PDFEclampsia, HELLP and PRES in a 16-week partial molar pregnancy.
BMJ Case Rep
June 2024
Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA
Article Synopsis
- Eclampsia spectrum disorders are serious pregnancy complications that typically occur after 20 weeks, but can manifest earlier in cases of molar pregnancies.
- A case study is presented about a woman in her mid-20s who, at 16 weeks of gestation, developed eclampsia and related complications after being diagnosed with a partial hydatidiform mole.
- The ultrasound and pathology confirmed a partial molar pregnancy with a specific genetic profile, emphasizing the need for early screening for hypertensive disorders in pregnant patients with molar pregnancies.
Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation.
Biochim Biophys Acta Mol Basis Dis
June 2024
The International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200000, China; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China; Shanghai Key Laboratory of Reproduction and Development, Shanghai 200011, China; Reproductive Medicine Center, International Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai 200030, China; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China; State Key Laboratory of Cardiology, Shanghai 200000, China. Electronic address:
Objectives: Gamete and embryo-foetal origins of adult diseases hypothesis proposes that adulthood chronic disorders are associated with adverse foetal and early life traits. Our study aimed to characterise developmental changes and underlying mechanisms of metabolic disorders in offspring of pre-eclampsia (PE) programmed pregnancy.
Methods: Nω-Nitro-l-arginine methyl ester hydrochloride (L-NAME) induced pre-eclampsia-like C57BL/6J mouse model was used.
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