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Effect of oxytocin nasal spray pretreatment on postoperative acute stress disorder in patients with accidental traumatic fracture: a single-centre prospective randomised controlled clinical trial study protocol.
BMJ Open
January 2025
Department of Anesthesiology, People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China
Introduction: Patients undergoing surgical procedures are often prone to developing acute stress disorder (ASD) postoperatively. Presently, oxytocin nasal spray has shown significant potential in the treatment of stress-related neuropsychiatric diseases. However, there are few reports on the use of oxytocin nasal spray in postoperative ASD, a condition that can potentially develop into a high-risk factor for post-traumatic stress disorder.
View Article and Find Full Text PDFFirst-in-human study on pharmacokinetics, safety, and tolerability of single and multiple escalating doses of PA9159 nasal spray, a highly potent glucocorticoid in healthy Chinese volunteers.
Eur J Pharm Sci
September 2024
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, PR China. Electronic address:
Article Synopsis
- PA9159, a new glucocorticoid nasal spray, was tested in healthy Chinese volunteers to assess its safety, tolerability, and effects on cortisol secretion during a first-in-human clinical study.
- The study involved 60 participants and utilized a double-blinded, randomized, placebo-controlled design with both single and multiple ascending dose cohorts, with doses ranging from 10-80 µg.
- Results indicated that PA9159 was safe and well-tolerated, with mild nasal side effects and minimal impact on morning serum cortisol levels, while pharmacokinetic measurements showed effective absorption and half-lives of around 8-21 hours across different dosing groups.
Evaluation of the stress-reducing effect of trace mineral injection in beef calves.
J Vet Intern Med
June 2023
Department of Animal and Poultry Sciences, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, Virginia, USA.
Background: Little is known about the effects of trace mineral supplementation on the stress response in beef calves.
Objectives: To investigate the effect of injectable trace mineral supplementation (ITM) on the stress response in beef calves exposed to different types of stress.
Animals: Thirty weaned Angus and Angus crossbred calves.
Intake of Lactiplantibacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress: A randomized, double blind, placebo-controlled study.
Physiol Behav
October 2020
Department of Psychology, Faculty of Education, Kristianstad University, Kristianstad, Sweden.
The intestine and the brain are connected via the brain-gut axis and the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response. The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) for four weeks could counteract elevated cortisol and inflammation levels in subjects with chronic stress that are exposed to an acute stress test (Trier Social Stress Test, TSST). Seventy participants were included, and 63 participants completed the study (LPHEAL9, n = 32; placebo, n = 31).
View Article and Find Full Text PDFVasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris.
J Dermatolog Treat
September 2019
a Centre de Pharmacologie Clinique Appliquée à la Dermatologie, Nice , France.
It is important to determine the vasoconstrictor potencies of topical corticosteroids used to treat psoriasis to ensure appropriate clinical use. To compare the vasoconstrictive potencies of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) (Cal/BD) cutaneous foam with other topical corticosteroids.
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