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Histone lysine methyltransferases and their specific methylation marks show significant changes in mouse testes from young to older ages.
Biogerontology
January 2025
Department of Histology and Embryology, Akdeniz University School of Medicine, Campus, 07070, Antalya, Türkiye.
Spermatogenesis is finely regulated by histone methylation, which is crucial for regulating gene expression and chromatin remodeling. Functional studies have demonstrated that the histone lysine methyltransferases (KMTs) SETD1B, CFP1, SETDB1, G9A, and SETD2 play pivotal roles in spermatogenesis through establishing the key histone methylation marks, H3K4me3, H3K9me2, H3K9me3, and H3K36me3, respectively. This study aimed to evaluate the spatiotemporal expression of these KMTs and methylation marks as well as senescence-associated β-galactosidase (β-GAL), transcriptional activity, and apoptosis rates in mouse testes during biological aging.
View Article and Find Full Text PDFEarly Detection of Testicular Sertoli Cell Tumor Through Physical Examination: A Case Report.
Cureus
December 2024
Medical Corps, Israel Defense Forces, Haifa, ISR.
Testicular tumors represent the most common solid organ malignancy in young and adult males. Sex cord-stromal tumors are the second-largest group of primary testicular cancers, after germ-cell tumors. Sertoli cell (SC) tumors of the testis are relatively rare, accounting for only a small fraction of testicular tumors.
View Article and Find Full Text PDFCeRNA profiling and the role in regulating gonadal development in gold pompano.
BMC Genomics
January 2025
MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences / Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Qingdao / Sanya, China.
Background: The golden pompano (Trachinotus ovatus) is an economically significant warm-water aquaculture species in China. The time required for sexual maturity of T. ovatus is relatively long.
View Article and Find Full Text PDFUtilization of the QuPath open-source software platform for analysis of mammalian spermatogenesis.
Biol Reprod
January 2025
Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC USA.
The adult mammalian testis is filled with seminiferous tubules, which contain somatic Sertoli cells along with germ cells undergoing all phases of spermatogenesis. During spermatogenesis in postnatal mice, male germ cells undergo at least 17 different nomenclature changes as they proceed through mitosis as spermatogonia (=8), meiosis as spermatocytes (=6), and spermiogenesis as spermatids (=3) [1-6]. Adding to this complexity, combinations of germ cells at each of these stages of development are clumped together along the length of the seminiferous tubules.
View Article and Find Full Text PDFStructural characteristics of a polysaccharide isolated from Potentilla anserina L. and its mitigating effect on Zearalenone-induced oxidative damage in Sertoli cells.
Int J Biol Macromol
January 2025
College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730030, China; Gansu Innovation Research Center for Swine Production Engineering and Technology, Lanzhou 730070, China. Electronic address:
The present study aims to characterize the structural features of a natural polysaccharide called PAP-1b extracted from the roots of Potentilla anserina L. and to evaluate its antioxidant activity. Structural characterization indicated that PAP-1b with a molecular weight of 1.
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