Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy.
Front Immunol
January 2025
Department of Surgery, Stanford School of Medicine, Stanford University Medical Center, Stanford, CA, United States.
Molecular characterization of tumors is essential to identify predictive biomarkers that inform treatment decisions and improve precision immunotherapy development and administration. However, challenges such as the heterogeneity of tumors and patient responses, limited efficacy of current biomarkers, and the predominant reliance on single-omics data, have hindered advances in accurately predicting treatment outcomes. Standard therapy generally applies a "one size fits all" approach, which not only provides ineffective or limited responses, but also an increased risk of off-target toxicities and acceleration of resistance mechanisms or adverse effects.
View Article and Find Full Text PDFBiotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies.
J Ethnopharmacol
January 2025
Department of Biopharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland; Department of Biochemistry and Toxicology, University of Life Sciences, Akademicka 13, 20-950 Lublin, Poland. Electronic address:
Background: The human gut microbiota plays a crucial role in various aspects of health, extending beyond digestion and nutrient absorption. Ganoderma lucidum (Reishi) and Hericium erinaceus (Lion's Mane), traditional medicinal mushrooms, have garnered interest due to their potential to exert positive health effects. The aim of our study was to investigate the molecular impact of Reishi and Lion's Mane on mood regulation through the gut-brain axis.
View Article and Find Full Text PDFThe small molecule peroxiredoxin mimetics restore growth factor signalings and reverse vascular remodeling.
Free Radic Biol Med
January 2025
Department of Life Science, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address:
Epidithio-diketopiperazine (ETP) compound is the family of natural fungal metabolites that are known to exert diverse biological effects, such as immunosuppression and anti-cancer activity, in higher animals. However, an enzyme-like catalytic activity or function of the ETP derivatives has not been reported. Here, we report the generation of novel thiol peroxidase mimetics that possess peroxide-reducing activity through strategic derivatization of the core ETP ring structure.
View Article and Find Full Text PDFuniversal stress protein contributes to persistence during growth arrest and paraquat-induced superoxide stress.
J Bacteriol
January 2025
Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Unlabelled: is one of the most virulent bacterial pathogens known and causes the disease tularemia, which can be fatal if untreated. This zoonotic and intracellular pathogen is exposed to diverse environmental and host stress factors that require an appropriate response to survive. However, the stress tolerance mechanisms used by to persist are not fully understood.
View Article and Find Full Text PDFLong-term dynamics of placozoan culture: emerging models for population and space biology.
Front Cell Dev Biol
January 2025
Departments of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
As the simplest free-living animal, (Placozoa) is emerging as a powerful paradigm to decipher molecular and cellular bases of behavior, enabling integrative studies at all levels of biological organization in the context of metazoan evolution and parallel origins of neural organization. However, the progress in this direction also depends on the ability to maintain a long-term culture of placozoans. Here, we report the dynamic of cultures over 11 years of observations from a starting clonal line, including 7 years of culturing under antibiotic (ampicillin) treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!