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Exploring novelty to unpack the black-box of motivation.
Behav Brain Sci
January 2025
Neuroelectronics Research Flanders (NERF), and Department of Neuroscience, KU Leuven, Leuven,
Murayama and Jach point out that we do not sufficiently understand the constructs and mental computations underlying higher-order motivated behaviors. Although this may be generally true, we would like to add and contribute to the discussion by outlining how interdisciplinary research on has advanced the study of learning and curiosity.
View Article and Find Full Text PDFP2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.
Theranostics
January 2025
Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland.
Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. The P2X7 receptor (P2X7R) is a cationic ATP-dependent membrane channel that is expressed throughout the brain.
View Article and Find Full Text PDFLipid Metabolic Heterogeneity during Early Embryogenesis Revealed by Hyper-3D Stimulated Raman Imaging.
Chem Biomed Imaging
January 2025
College of Biomedical Engineering & Instrument Science, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310058, China.
Studying embryogenesis is fundamental to understanding developmental biology and reproductive medicine. Its process requires precise spatiotemporal regulations in which lipid metabolism plays a crucial role. However, the spatial dynamics of lipid species at the subcellular level remains obscure due to technical limitations.
View Article and Find Full Text PDFLong-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness.
JACC Asia
January 2025
Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time in target range (TTR) for BP since childhood on the risk of arterial stiffness in midlife remains unclear.
Objectives: The purpose of this study was to determine the independent association of TTR for systolic blood pressure (SBP) from childhood to midlife with arterial stiffness in adulthood.
Investigating the relationship between prenatal androgen exposure and sleep quality: a comprehensive study using anthropometric measurements, questionnaires, actigraphy, and polysomnography.
Front Endocrinol (Lausanne)
January 2025
Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, Poland.
Background: The 2D:4D digit ratio (DR), representing the relative length of the index finger to the ring finger, is an anthropometric marker that shows sexual dimorphism, with males typically having a lower ratio than females. This parameter is linked to prenatal androgen exposure (PAE), which influences sexual differentiation of the brain and behavior. This study aimed to investigate the correlation between PAE and sleep among young adults.
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