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An alkaloid-rich phytopharmaceutical prepared from Qing Dai against IL-17A-induced psoriasis.
J Ethnopharmacol
January 2024
Chinese Medicine Research Center, China Medical University, Taichung, 40402, Taiwan; Research Center for Traditional Chinese Medicine, China Medical University Hospital, Taichung, 40447, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung, 40447, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan. Electronic address:
Article Synopsis
- Psoriasis is a chronic skin condition linked to immune system issues that severely impacts quality of life, and Qing Dai (a traditional Chinese medicine) has been found to reduce harmful interleukin-17A levels in affected skin.
- The study focuses on creating INM-A, an alkaloid-rich extract from Qing Dai, to investigate its anti-psoriatic effects in both lab tests and a mouse model.
- Results showed that INM-A contains seven active alkaloids, successfully improves skin conditions in psoriatic mice, lowers IL-17A levels, and reduces inflammation and oxidative stress in skin cells, indicating its potential as a treatment for psoriasis.
Good Practices for Histological Analysis of the Annual Killifish (Nothobranchiidae).
Cold Spring Harb Protoc
November 2022
Institute of Vertebrate Biology, Czech Academy of Sciences, Brno 603 00, Czech Republic.
Paraffin histology is one of the most important and commonly used laboratory techniques enabling the study of the microscopic structure of animal and plant tissues. This technique uses paraffin wax, which in liquid form impregnates fixed and dehydrated tissues and allows the preparation of thin sections when solidified in blocks. This protocol on good practices in paraffin histology of (Nothobranchiidae) summarizes the authors' current experience in terms of technique, evaluation, and interpretation of sectioned tissues.
View Article and Find Full Text PDFPreservation and Processing of Intestinal Tissue for the Assessment of Histopathology.
Methods Mol Biol
March 2021
Freie Universität Berlin, Department of Veterinary Medicine, Institute of Veterinary Anatomy, Berlin, Germany.
The intestine is often examined histologically in connection with allergies and in search for pathological changes. To be able to examine the intestine histologically with a microscope, it must be sampled and processed correctly. For microscopic analysis, the samples have to be cut into thin sections, stained, and mounted on slides.
View Article and Find Full Text PDFPhoto-induced and Rapid Labeling of Tetrazine-Bearing Proteins via Cyclopropenone-Caged Bicyclononynes.
Angew Chem Int Ed Engl
October 2019
Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Group of Synthetic Biochemistry, Technical University of Munich, Institute for Advanced Study, Lichtenbergstr. 4, 85748, Garching, Germany.
Inverse electron-demand Diels-Alder cycloadditions (iEDDAC) between tetrazines and strained alkenes/alkynes have emerged as essential tools for studying and manipulating biomolecules. A light-triggered version of iEDDAC (photo-iEDDAC) is presented that confers spatio-temporal control to bioorthogonal labeling in vitro and in cellulo. A cyclopropenone-caged dibenzoannulated bicyclo[6.
View Article and Find Full Text PDFDeath by electrocution: Histological technique for copper detection on the electric mark.
Forensic Sci Int
July 2016
Cameron Forensic Medical Sciences, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK.
The current observation of deaths by electrocution, both for domestic and work-related accidents as well as those in other contexts, has deepened the scope of investigation into electric marks, especially from the histological point of view. This is one of the few investigation tools that may lead to the diagnosis of death by electrocution in this distinct area, bearing in mind the diagnostic difficulties that this type of fatality presents. Our attention has been placed on the phenomenon of metallization.
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