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Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus.
Sci Rep
April 2020
Istituto Superiore di Sanità, National Centre for pre-clinical and clinical drug research and evaluation, Pharmacological research and experimental therapy Unit, 00166, Rome, Italy.
LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. In systemic lupus erythematosus (SLE), LL37 also triggers IFN-I in pDCs and is target of pathogenic autoantibodies.
View Article and Find Full Text PDFResting-state functional connectivity MRI analysis in Human Immunodeficiency Virus and Hepatitis C Virus co-infected subjects. A pilot study.
Eur J Radiol
May 2018
Department of Radiolgy, AOU of Cagliari, University of Cagliari, Italy.
Background And Purpose: Hepatitis C virus (HCV) co-infection's role on cognitive impairment of human immunodeficiency virus (HIV) positive patients is still debated and functional neuroimaging evaluation on this matter is lacking. To provide further insight about HCV's neuro-effects on HIV associated neurocognitive disorder (HAND), we performed a pilot resting state (RS) functional connectivity magnetic resonance imaging (fcMRI) study to find eventual functional connectivity alteration that could reflect HCV related cognitive performance degradation.
Methods: Eighteen patients (8 HIV, 10 HIV + HCV), either impaired or not impaired, were assessed with RS fcMRI.
Quantification of organ motion based on an adaptive image-based scale invariant feature method.
Med Phys
November 2013
Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, piazza L. Da Vinci 32, Milano 20133, Italy.
Purpose: The availability of corresponding landmarks in IGRT image series allows quantifying the inter and intrafractional motion of internal organs. In this study, an approach for the automatic localization of anatomical landmarks is presented, with the aim of describing the nonrigid motion of anatomo-pathological structures in radiotherapy treatments according to local image contrast.
Methods: An adaptive scale invariant feature transform (SIFT) was developed from the integration of a standard 3D SIFT approach with a local image-based contrast definition.
Effects of atropine and propranolol on lung inflammation in experimental envenomation: comparison of two buthidae venoms.
J Venom Anim Toxins Incl Trop Dis
April 2013
USTHB, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumedienne, BP 32 El Alia, Bab Ezzouar, 16111, Algiers, Algeria.
Background: Previous works had shown that scorpion venom induced neurotransmitter elevation and an inflammatory response associated with various anatomo-pathological modifications. The most dangerous scorpions species in Algeria responsible for these effects are Androctonus australis hector (Aah) and Androctonus amoreuxi (Aam).
Results: Comparison of the physiopathological effects induced by the two venoms showed differences in the kinetic of cytokine release and in lung injury.
Anatomical Substrate and Scalp EEG Markers are Correlated in Subjects with Cognitive Impairment and Alzheimer's Disease.
Front Psychiatry
July 2011
Istituto Di Ricovero e Cura a Carattere Scientifico S. Giovanni di Dio Fatebenefratelli Brescia, Italy.
Dementia is a syndromic diagnosis, encompassing various stage of severity and different anatomo-physiological substrates. The hippocampus is one of the first and most affected brain regions affected by both Alzheimer's disease (AD) and mild cognitive impairment (MCI). Moreover, chronic cerebrovascular disease (CVD) is one of the major risk factor for developing dementia.
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