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Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures.
Pharmaceuticals (Basel)
December 2024
Differentiation and Cancer Group, Institute for Research and Innovation in Health (i3S) of the University of Porto, 4200-135 Porto, Portugal.
Background: Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC) treatment. Although many patients initially respond to chemotherapy, the majority of them relapse due to Carboplatin and Paclitaxel resistance. Drug repurposing has surfaced as a potentially effective strategy that works synergically with standard chemotherapy to bypass chemoresistance.
View Article and Find Full Text PDFOptimally designed PEGylatied arabinoxylan paclitaxel nano-micelles as alternative delivery for Abraxane®: A potential targeted therapy against breast and lung cancers.
Int J Biol Macromol
December 2024
Group of Bionanotechnology and Molecular Cell Biology, Nanomedicine department, Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt. Electronic address:
Paclitaxel (PTX) binds to spindle microtubules and inhibits mitotic division leading to cell death. However, its wide distribution, high absorption, and less selectively, minimize its application in cancer clinics. In this study, isolated arabinoxylans were used to encapsulate PTX, and then both were covered by polyethylene glycol conjugated to folic acid (FA), to strengthen its specificity to cancerous cells.
View Article and Find Full Text PDFPlatinum Compound on Gold-Magnesia Hybrid Structure: A Theoretical Investigation on Adsorption, Hydrolysis, and Interaction with DNA Purine Bases.
Nanomaterials (Basel)
December 2024
Department of Chemistry and Chemical Engineering, Taiyuan Institute of Technology, Taiyuan 030008, China.
Cisplatin-based platinum compounds are important clinical chemotherapeutic agents that participate in most tumor chemotherapy regimens. Through density-functional theory calculations, the formation and stability of the inorganic oxide carrier, the mechanisms of the hydrolysis reaction of the activated platinum compound, and its binding mechanism with DNA bases can be studied. The higher the oxidation state of Pt (II to IV), the more electrons transfer from the magnesia-gold composite material to the platinum compound.
View Article and Find Full Text PDFCocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer.
Acta Pharm Sin B
October 2024
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Multidrug resistance (MDR), the major mechanism by which various cancers develop specific resistance to therapeutic agents, has set up enormous obstacles to many forms of tumor chemotherapy. Traditional cocktail therapy administration, based on the combination of multiple drugs for anti-MDR chemotherapy, often suffers from inconsistent pharmacokinetic behaviors that cannot act synchronously on the lesions, leading to limited pharmacodynamic outcomes. Despite the emergence of nanomedicines, which has improved chemotherapeutic drugs' bioavailability and therapeutic effect on clinical application, these monotherapy-based nano-formulations still show poor progression in overcoming MDR.
View Article and Find Full Text PDFThe combination of FLCWK with 5-FU inhibits colon cancer and multidrug resistance by activating PXR to suppress the IL-6/STAT3 pathway.
J Cell Mol Med
November 2024
Department of Rehabilitation therapeutics, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Article Synopsis
- 5-fluorouracil (5-FU) is commonly used to treat colon cancer but often faces issues like drug resistance and poor effectiveness, highlighting the need for new therapies like Fengliao Changweikang (FLCWK).
- This study investigated how FLCWK could enhance 5-FU's effectiveness by manipulating the pregnane X receptor (PXR) in colon cancer cells, revealing that while higher PXR levels increased therapeutic response, they also boosted resistance.
- The combination of FLCWK and 5-FU was found to reduce the expression of P-glycoprotein, reverse resistance mechanisms, and effectively inhibit colon cancer progression in mouse models, suggesting FLCWK's potential in improving
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