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Herbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders.
Nutrients
December 2024
Food Chemistry and Nutraceutical Laboratory, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Background: Three herbal extracts ( Willd., Lorentz, and L.) were mixed with three essential oils ( Mill.
View Article and Find Full Text PDFThe antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability.
Front Oncol
December 2024
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Glabridin, a flavonoid derived from the plant , has garnered significant attention due to its diverse pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, hypolipidemic, and hypoglycemic activities. Studies have shown that glabridin exhibits substantial antitumor activity by modulating the proliferation, apoptosis, metastasis, and invasion of cancer cells through the targeting of various signaling pathways, thus indicating its potential as a therapeutic agent for malignant tumors. To enhance its solubility, stability, and bioavailability, several drug delivery systems have been developed, including liposomes, cyclodextrin inclusion complexes, nanoparticles, and polymeric micelles.
View Article and Find Full Text PDFArticle Synopsis
- Peptic ulcer disease is common globally, and current treatments have limitations, leading to interest in alternative therapies from medicinal plants.
- A review analyzed 54 North African plants known for their anti-ulcer properties, highlighting several effective species like licorice, chamomile, and pomegranate, which contain beneficial compounds like flavonoids and tannins.
- Although many of these plants show significant potential for treating peptic ulcers in studies, more clinical research is needed to confirm their safety and effectiveness in humans.
Honey-fried licorice in the treatment of arrhythmia: Structure elucidation and the mechanism of antiarrhythmic activity.
Phytomedicine
January 2025
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education (Ningxia Medical University), Yinchuan 750004, China. Electronic address:
Aim Of The Study: To evaluate the therapeutic mechanism of Honey-fried licorice on arrhythmia, to explore the distribution of main components of Honey-fried licorice in vivo before and after processing, and to elucidate the active ingredient of Honey-fried licorice on arrhythmia.
Materials And Methods: UPLC-Q-TOF/MS were used to analyze the common and different components of raw and honey-fried licorice before and after processing. Yin deficiency syndrome was established by continuous irritability and water platform sleep deprivation, and then ventricular arrhythmia model was established by injection of calcium chloride into the tail vein.
A step-by-step progressive strategy exploring whole metabolic profiles in vivo for Polygalae Radix with/without licorice.
Phytochem Anal
September 2024
National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Article Synopsis
- Polygalae Radix (PR) is beneficial for treating various diseases, but there's limited research on aromatic carboxylic acids (ACAs) due to detection challenges, particularly for metabolites within the m/z range of 100-2000.
- *The study aimed to explore PR’s metabolism with and without licorice (LP), utilizing advanced techniques like UPLC-MS and stable isotope derivatization (SILD) to analyze metabolites across different body fluids and tissues.
- *Results revealed 85 polygala metabolites with 11 large metabolites and 8 ACAs identified, emphasizing the role of small molecular metabolites in diseases like Alzheimer's through targeted network pharmacology and highlighting LP's influence on neural pathways.*
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