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Identification of Factors Determining Patterns of Serum C-Reactive Protein Level Reduction in Response to Treatment Initiation in Patients with Drug-Susceptible Pulmonary Tuberculosis.
Antibiotics (Basel)
December 2024
Pharmacogenetic and Precision Medicine Laboratory, Pharmaceutical Education and Research Centre, Riga Stradins University, Konsula Street 21, LV1007 Riga, Latvia.
Serum C-reactive protein (CRP) levels vary depending on radiological and bacteriological findings at the time of tuberculosis (TB) diagnosis. However, the utility of this biomarker in monitoring response to anti-TB treatment and identifying patients at risk of treatment failure is not well established. This study evaluated the impact of patients' baseline characteristics and anti-TB drug plasma exposure on the early reduction in serum CRP levels and its relationship with treatment response.
View Article and Find Full Text PDFImproving Septicemia Diagnostics: A Comparative Analysis of Direct and Post-Culture MALDI-TOF MS Methods for Bacterial Identification.
Tunis Med
December 2024
Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.
Article Synopsis
- Bloodstream infections need quick bacterial identification for effective treatment, with traditional methods being slow.
- The study compared direct identification using MALDI-TOF MS with the post-culture method, finding that while direct identification had a lower success rate (64.8%), it provided results in under an hour.
- Despite its limitations, the direct method could significantly enhance diagnosis speed, making it a potentially valuable tool in conjunction with established methods.
Tuberculosis screening among cough suppressant buyers in pharmacies and drug outlets in Guinea: a cross-sectional study.
BMJ Open Respir Res
December 2024
World Health Organization, Geneva, Switzerland.
Article Synopsis
- Tuberculosis (TB) is a major health issue in Guinea, with many cases going undetected; an intensified case finding strategy involved pharmacies and drug outlets targeting customers buying cough suppressants.
- A study conducted in Conakry involved screening 916 individuals for TB, resulting in a 14% bacteriologically confirmed TB diagnosis, with gender and age influencing diagnosis likelihood.
- The intervention cost approximately $32.66 per person referred and $237.45 for those diagnosed, showing that using pharmacies as a TB detection point is both feasible and effective in boosting detection rates.
Green walls for greywater treatment: A comprehensive review of operational parameters and climate influence on treatment performance.
Water Res
December 2024
CERIS, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisboa 1049-001, Portugal.
Green walls for greywater treatment have emerged as a solution to increase green spaces in densely urbanized areas while providing treated greywater for reuse. Over the past decade, numerous studies have focused on optimizing these systems, though most address specific operational conditions and evaluate a limited set of performance parameters. This review synthesizes the existing literature using a meta-analysis to identify key operational factors and treatment performance metrics.
View Article and Find Full Text PDFComparison of nasopharyngeal bacteriological profile between patients with diabetes and healthy individuals in Accra, Ghana.
BMC Res Notes
December 2024
Department of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Background: The nasopharynx is characterised by a rich microbial diversity, making it an important endogenous reservoir for respiratory infections. People living with diabetes (PLWD) have a high risk for acquisition of respiratory tract infections, but their nasopharyngeal bacterial flora have rarely been investigated.
Aim: To investigate the nasopharyngeal bacterial flora among PLWD and non-diabetics at the Korle Bu Teaching Hospital in Accra.
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