AI Article Synopsis

Article Abstract

Changes of a number of functions of beta-receptor complex mechanism have been analyzed by means of the microwave-dielectrometry method on native erythrocytes at various stages of cardiovascular pathology. The control scheme of beta-receptor complex has been analyzed in the adenylate cyclase system and the regions have been extracted which are subjected to an attack of pathological factors of the effect.

Download full-text PDF

Source

Publication Analysis

Top Keywords

beta-receptor complex
8
[molecular mechanisms
4
mechanisms development
4
development cardiovascular
4
cardiovascular pathology]
4
pathology] changes
4
changes number
4
number functions
4
functions beta-receptor
4
complex mechanism
4

Similar Publications

Cullin-5 (Cul5) coordinates assembly of cullin-RING-E3 ubiquitin (Ub) ligase (CRL) complexes that include Suppressor of Cytokine Signaling (SOCS)-box-containing proteins. The SOCS-box proteins function to recruit specific substrates to the complex for ubiquitination and degradation. In hematopoiesis, SOCS-box proteins are best known for regulating the actions of cytokines that utilize the JAK-STAT signaling pathway.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how high glucose levels in diabetes lead to kidney cell damage through the activation of a signaling pathway involving DJ-1 and PTEN.
  • DJ-1 is found to be upregulated in kidney cells under high glucose conditions, which triggers the Akt/mTORC1 signaling pathway, resulting in cell growth and fibrosis.
  • The research indicates that inhibiting DJ-1 can prevent glucose-induced cell growth and damage, while overexpressing DJ-1 replicates the harmful effects, highlighting its role in renal injury related to diabetes.
View Article and Find Full Text PDF

Interleukin-11 receptor is an alternative α-receptor for interleukin-6 and the chimeric cytokine IC7.

FEBS J

October 2024

Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany.

The cytokine interleukin 6 (IL-6) signals via the IL-6 α-receptor (IL-6Rα or IL-6R) in complex with the gp130 β-receptor. Cell type restricted expression of the IL-6R limits the action of IL-6 mainly to hepatocytes and some immune cells. Here, we show that IL-6 also binds to the IL-11 α receptor (IL-11Rα or IL-11R) and induces signaling via IL-11R:gp130 complexes, albeit with a lower affinity compared to IL-11.

View Article and Find Full Text PDF

Heparin-binding protein and sepsis-induced coagulopathy: Modulation of coagulation and fibrinolysis via the TGF-β signalling pathway.

Thromb Res

December 2024

Department of Critical Care Medicine, the First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China. Electronic address:

Article Synopsis
  • Heparin-binding protein (HBP) levels are found to be higher in patients with sepsis and linked to a higher risk of developing disseminated intravascular coagulation (DIC).
  • A study involving 538 sepsis patients identified a cutoff level of 37.5 ng/mL for HBP, which indicated a significant association with DIC and other biomarkers.
  • HBP was shown to activate the TGF-β signaling pathway, leading to increased levels of fibrinogen and plasminogen activator inhibitor-1 (PAI-1), which may contribute to coagulation complications in sepsis.
View Article and Find Full Text PDF

Globally, cancer is one of the leading causes of death. Resistance to conventional medications, such as chemotherapy and radiation, continues to be a significant challenge in the treatment of cancer despite the availability of numerous medicines. Therefore, the highest priority is to hunt for new therapeutic agents.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!