AI Article Synopsis
- The study examined the pituitary-adrenal function in seven asthmatic patients after a year of daily inhalations of beclomethasone dipropionate (BDP) at doses of 800 to 1,000 micrograms.
- None of the subjects had taken oral corticosteroids for at least six months, suggesting a stable baseline for evaluating the effects of BDP.
- Results showed normal circadian rhythms of plasma ACTH and cortisol, as well as normal urinary excretion rates of key hormones, indicating that long-term BDP use does not suppress pituitary-adrenal function.
Article Abstract
The pituitary-adrenal function was studied in seven asthmatic subjects who had been received daily inhalations of 800 to 1,000 micrograms of beclomethasone dipropionate (BDP) over a year. None of the subjects had taken oral corticosteroids for at least six months prior to the study. As indices of pituitary-adrenal function, 1) circadian rhythm of plasma ACTH and cortisol, 2) urine 17-OHCS and 17-KS, and 3) the response of cortisol in rapid ACTH test were examined. All subjects showed normal circadian rhythms of plasma ACTH and cortisol levels. Urinary 17-OHCS and 17-KS excretions over a 24-hour period were also within the normal range. Plasma cortisol levels in the rapid ACTH test were significantly increased and judged as normal responses in all subjects. These results indicate that long-term treatment with BDP ranging from 800 to 1,000 micrograms/day induces no suppressive effect on the pituitary-adrenal function.
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