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Impact of Acute Myocardial Injury on Short- and Long-Term Outcomes in Patients With Primary Intracerebral Hemorrhage.
J Am Heart Assoc
January 2025
Department of Neurology The Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China.
Background: Myocardial injury is common after brain injury; however, few studies have reported serial cardiac troponin (cTn) measurements to distinguish whether the myocardial injury is acute or chronic. The fourth Universal Definition of Myocardial Infarction introduced for the first time the criteria for acute myocardial injury (AMI). We aimed to investigate the prevalence and prognostic implications of AMI in primary intracerebral hemorrhage.
View Article and Find Full Text PDFSpirometric pattern and cardiovascular risk: a prospective study of 0.3 million Chinese never-smokers.
Lancet Reg Health West Pac
January 2025
Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Article Synopsis
- Non-smoking patients with restrictive spirometric patterns (RSP) or airflow obstruction (AFO) are at a higher risk of cardiovascular disease (CVD), particularly acute myocardial infarction and heart failure.
- During a 12-year follow-up study, risks were notably elevated in women, especially underweight individuals, with the severity of AFO and reduced lung function contributing to increased risks.
- The study highlights the need for further research to understand the impact of body shape on CVD risk among non-smokers with these respiratory conditions.
Impaired cerebral microvascular reactivity and endothelial SK channel activity in a streptozotocin-treated mouse model of Alzheimer's disease.
J Alzheimers Dis
January 2025
Division of Cardiothoracic Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
Article Synopsis
- Alzheimer's disease (AD) is characterized by various pathological features including amyloid-β deposition and tau hyperphosphorylation, with cerebral microvascular dysfunction likely playing a role in its progression.
- Researchers investigated the microvascular responses and potassium channel activity in an AD mouse model induced by streptozotocin (STZ), using behavioral tests and cellular assays.
- The study found that STZ-AD mice showed poorer performance on behavioral tests and had impaired microvascular responses, which were further deteriorated by exposure to soluble Aβ, indicating a potential link between microvascular dysfunction and AD pathology.
A novel computational method for rodent electrographic recording and analysis using off-the-shelf intracerebral depth electrodes.
MethodsX
June 2025
Medical College of Wisconsin, Department of Neurosurgery, 8701 Watertown Plank Road, Milwaukee, WI, 53226.
Electrographic recording of brain activity through either surface electrodes (electroencephalography, EEG) or implanted electrodes (electrocorticography, ECOG) are valuable research tools in neuroscience across many disciplines, including epilepsy, sleep science and more. Research techniques to perform recordings in rodents are wide-ranging and often require custom parts that may not be readily available. Moreover, the information required to connect individual components is often limited and can therefore be challenging to implement.
View Article and Find Full Text PDFPotential challenges to harmonize post-stroke cognitive assessment and its prognostic value: a narrative review.
J Med Life
November 2024
Department of Medical Physics and Biophysics, Medical University-Pleven, Pleven, Bulgaria.
With advances in scientific and clinical knowledge, stroke has evolved from a major cause of death to a chronic condition affecting the daily lives of sufferers, their relatives, and society. Post-stroke cognitive impairment (PSCI) is common even among individuals with good neurological recovery. When deciding on interventions aimed to improve the life quality of post-stroke patients, identifying those at high risk of cognitive decline proves crucial.
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