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PACT-UK (PAncreatic Cancer reporting Template-UK): a cross-specialty multi-institutional consensus panel development of a standardised radiological reporting proforma for pancreatic cancer.
BMJ Oncol
November 2023
Department of Radiology, St James's University Hospital, Leeds, UK.
Objective: Appropriate staging of pancreatic cancer is essential to ensure patients are offered all treatment options. This multispecialty national collaborative consensus project aimed to develop a succinct radiological reporting template, using the concept of structured reporting, to allow a more standardised means of reporting pancreatic cancer and ultimately optimise both patient care and research protocol design.
Methods And Analysis: In stage one, a core group of stakeholders (oncologists, radiologists and surgeons) identified the current landscape of radiological reporting, including a blinded radiological validation study and a national survey of consultant HPB surgeons.
Biocompatible covalent reactive groups (CRGs) play pivotal roles in several areas of chemical biology and the life sciences, including targeted covalent inhibitor design and preparation of advanced biologic drugs, such as antibody-drug conjugates. In this study, we present the discovery that the small, chlorinated polyketide natural product cyclohelminthiol II (CHM-II) acts as a new type of cysteine/thiol-targeting CRG incorporating both reversible and irreversible reactivity. We devise the first syntheses of four simple cyclohelminthols, (±)-cyclohelminthol I-IV, with selective chlorinations (at C and C) and a Ni-catalyzed reductive cross coupling between an enone, a vinyl bromide and triethylsilyl chloride as the key steps.
View Article and Find Full Text PDFGenetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER.
JACC Adv
February 2025
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Longitudinal Evaluation of Genetic Hypertrophic Cardiomyopathy Penetrance and Transition to Disease in an Academic Biobank.
JACC Adv
February 2025
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Paper and Pencil Design of Color-Pure Organic Emitters: The Curious Case of Xanthene Dyes.
J Phys Chem A
January 2025
Madrid Institute for Advanced Studies, IMDEA Nanoscience, C/Faraday 9, Ciudad Universitaria de Cantoblanco, Madrid 28049, Spain.
The quest for color-pure emitters for multicolor bioimaging as well as for ultrahigh definition organic light-emitting diodes demands facile design concepts to avoid tedious synthetic or computational trial-and-error procedures. We have recently presented a simple recipe to construct color-pure blue emitters, which combines basic resonance structure and frontier molecular orbital treatments; this recipe applies to multiresonant type emitters and allows to enlarge the chemical space toward novel structural motifs. In the current work, we show that such fundamental considerations further apply to the structurally entirely different family of xanthene dyes.
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