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Anti-inflammatory effect of sea buckthorn in an HCl-induced cystitis rat model.
Investig Clin Urol
January 2025
Department of Urology, Ewha Womans University College of Medicine, Seoul, Korea.
Purpose: Although the mechanism underlying interstitial cystitis/bladder pain syndrome (IC/BPS) remains unclear, oxidative stress is suggested to be implicated in IC/BPS development. Sea buckthorn (SB; L.) contains several compounds with antioxidant properties.
View Article and Find Full Text PDFRetrospective study of incidence/prevalence of pigmentary maculopathy and retinopathy in patients receiving pentosan polysulfate sodium.
PLoS One
January 2025
Verana Health, San Francisco, CA, United States of America.
Purpose: To evaluate prevalence and incidence rates of pigmentary maculopathy and retinopathy (PM/PR), and visual acuity (VA) changes in patients exposed to pentosan polysulfate sodium (PPS) and in patients with interstitial cystitis (IC) not exposed to PPS.
Methods: This is a retrospective cohort study (January 2015-March 2021) which included adult de-identified patients from the American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) and Komodo Health database. Three patient cohorts were identified: two PPS-exposed patient cohorts, and Non-PPS-exposed IC patient cohort.
Preparation and structural characterization of a sulfated octasaccharide with heparin-like anticoagulant activity.
Carbohydr Polym
January 2025
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China; Key Laboratory of Metabolic Engineering and Biosynthesis Technology, Ministry of Industry and Information Technology, 210094, China. Electronic address:
Article Synopsis
- Heparins, derived from animal tissues, have supply limitations and risks like bleeding and thrombocytopenia, prompting research into synthetic alternatives.
- A new approach synthesized a heparin-like anticoagulant, sulfated octasaccharide (SRO), demonstrating effective anticoagulant activity in mice and humans with less bleeding risk.
- This synthetic product, named octaparin, offers a promising replacement for traditional animal-sourced heparin.
Comparative Effects of Acetate- and Citrate-Based Dialysates on Dialysis Dose and Protein-Bound Uremic Toxins in Hemodiafiltration Patients: Exploring the Impact of Calcium and Magnesium Concentrations.
Toxins (Basel)
October 2024
Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, Spain.
Article Synopsis
- Modern hemodialysis typically uses acetate as a buffer, which has been associated with chronic inflammation, while citrate is being explored as a potential alternative for dialysate.
- This study compares the efficacy of acetate- and citrate-based dialysates in terms of dialysis efficiency and the removal of protein-bound uremic toxins in patients undergoing hemodiafiltration.
- Results showed no significant differences in overall dialysis doses or most toxin reduction, but lower calcium and magnesium citrate dialysates led to better clearance of p-cresyl sulfate, indicating a need for further research to optimize dialysate formulas.
Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.
Altern Ther Health Med
October 2024
Article Synopsis
- Moderate to severe interstitial cystitis (bladder pain syndrome) currently lacks effective long-term treatments, with pentosan polysulfate having limitations and potential side effects.
- A study involving 12 women aged 39-76 tested BPC-157, an unapproved peptide, via bladder injections to evaluate its safety and efficacy for interstitial cystitis.
- Results showed that 10 out of 12 patients experienced complete symptom resolution after one injection, while the remaining 2 reported significant improvement, marking the first positive report on BPC-157 for this condition.
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