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First Detection of Hepatitis B Virus Subgenotype A5, and Characterization of Occult Infection and Hepatocellular Carcinoma-Related Mutations in Latin American and African Immigrants in Brazil.
Int J Mol Sci
August 2024
Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.
Article Synopsis
- This study investigates the molecular characteristics of hepatitis B virus (HBV) among socially vulnerable immigrants in Brazil to assess the introduction of rare HBV strains.
- Researchers tested serum samples from 102 immigrants with positive HBV serology, discovering various HBV subgenotypes, including the first report of subgenotype A5 in Brazil.
- The findings highlight the need for improved prevention and control strategies by understanding the genetic diversity of HBV within immigrant communities, which could enhance public health initiatives for both immigrants and the broader population.
Updates on Hepatitis B Virus (HBV) Infection 2.0.
Microorganisms
November 2023
Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular (CMBC), Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas 1020A, Venezuela.
Hepatitis B is a "silent epidemic" that is fifty to a hundred (50-100) times more infectious than HIV and is a potentially life-threatening liver infection [...
View Article and Find Full Text PDFRecommendations by the Spanish Society of Rheumatology on risk management of biological treatment and JAK inhibitors in patients with rheumatoid arthritis.
Reumatol Clin (Engl Ed)
December 2023
Servicio de Reumatología, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain.
Objective: To present recommendations based on the available evidence and the consensus of experts, for risk management of biological treatment and JAK inhibitors in patients with rheumatoid arthritis.
Methods: Clinical research questions relevant to the purpose of the document were identified. These questions were reformulated in PICO format (patient, intervention, comparison, outcome or outcome) by a panel of experts, selected based on their experience in the area.
A Synopsis of Hepatitis C Virus Treatments and Future Perspectives.
Curr Issues Mol Biol
October 2023
Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, 779 00 Olomouc, Czech Republic.
Hepatitis C virus (HCV) infection is a worldwide public health problem. Chronic infection with HCV can lead to liver cirrhosis or cancer. Although some immune-competent individuals can clear the virus, others develop chronic HCV disease due to viral mutations or an impaired immune response.
View Article and Find Full Text PDFHepatitis B eradication: vaccine as a key player.
Am J Transl Res
August 2023
Institut National de la Santé et de la Recherche Médicale (Inserm) U1052, Centre de Recherche en Cancérologie de Lyon (CRCL) 151 Cours Albert Thomas, 69003 Lyon, France.
Objective: Despite the availability of a highly effective and safe vaccine against hepatitis B virus (HBV) infection for 40 years, still almost 300 million persons are estimated to be chronically infected by this virus worldwide. The World Health Organization (WHO) has proposed a plan for hepatitis elimination by 2030. However, several factors, such as the reduction and limitation in vaccination campaigns or vaccine hesitancy (VH) in some regions of the World, might have played a role in limiting the worldwide coverage of hepatitis B prophylaxis.
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