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[Determination of Gene Mutations Associated with Macrolide and Fluoroquinolone Resistance in Patients Infected with Mycoplasma genitalium].
Mikrobiyol Bul
October 2024
Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Türkiye.
A sexually transmitted bacterium, Mycoplasma genitalium has varying rates of reported resistance to macrolide and some fluoroquinolone group antimicrobials recommended for the treatment of its infections. It is currently recommended that the treatment of these must be planned according to macrolide resistance status. The aim of this study was to determine the presence of macrolide resistance associated mutations (MRM) and fluoroquinolone resistance associated mutations (QRM) in patients infected with M.
View Article and Find Full Text PDFPrevalence and Clinical Aspects of Infection among High-Risk Women in Karaj, Iran.
Iran J Parasitol
January 2024
Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, Iran.
Background: Trichomoniasis is a common sexually transmitted infection (STI) caused by the protozoan which causes health and emotional damages to the sufferers annually. We aimed to investigate the prevalence of and its related risk factors among the high-risk women in the city of Karaj, central Iran.
Methods: This cross-sectional study was conducted between October 2021 and September 2022.
Cannabinoids as cytotoxic agents and potential modulators of the human parasite Trichomonas vaginalis.
Biomed Pharmacother
December 2024
Structural Biology Laboratory, Oswaldo Cruz Institution, Fiocruz, Rio de Janeiro, Brazil; Programa de Pós-graduação em Biologia Celular e Molecular, Oswaldo Cruz Institution, Fiocruz, Rio de Janeiro, Brazil. Electronic address:
Trichomoniasis, a globally prevalent sexually transmitted infection caused by Trichomonas vaginalis, affects approximately 278 million people each year. It presents a challenge due to resistance to the current treatment, Metronidazole (MTZ), which is also associated with side effects. Cannabis sativa, with more than 100 phytocannabinoids and numerous studies for therapeutic applications, including parasitic infections, has undergone a significant shift in acceptance worldwide, highlighted by legalizations and substantial revenue projections.
View Article and Find Full Text PDFIron triggers PI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP signaling crucial for multiple pathogenic activities of the parasitic protozoan .
mBio
December 2024
Department of Tropical Medicine and Parasitology, College of Medicine, National Taiwan University, Taipei, Taiwan.
is the etiologic agent of trichomoniasis, one of the most common non-viral sexually transmitted infections globally. Our previous work reported the role of phosphatidylinositol 4,5-bisphosphates (PIP) signaling in the actin-dependent pathogenicity of . This study further demonstrated that iron transiently regulated phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) proteostasis and its complex formation with an active ADP ribosylation factor Arf220, facilitating co-trafficking to the plasma membrane, crucial for PIP production.
View Article and Find Full Text PDFRole of histone modification in chromatin-mediated transcriptional repression in protozoan parasite Trichomonas vaginalis.
BMB Rep
December 2024
Department of Tropical Medicine, Institute of Tropical Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Trichomonas vaginalis is an extracellular flagellated protozoan responsible for trichomoniasis, one of the most prevalent nonviral sexually transmitted infections. To persist in its host, T. vaginalis employs sophisticated gene regulation mechanisms to adapt to hostile environmental conditions.
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