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Introduction: Differentiated thyroid cancer (DTC) is the most common type of endocrine malignancy, with rising incidence over recent decades. Despite a favorable prognosis, DTC management remains complex, often involving thyroidectomy followed by radioactive iodine (RAI) therapy. While RAI is crucial for patient outcomes, its efficacy varies, necessitating the identification of predictors for treatment response.
View Article and Find Full Text PDFContribution of neck ultrasonography to patient management in patients with differentiated thyroid carcinoma with excellent response to therapy.
Endocrine
December 2024
Department of Nuclear Medicine, Ege University Faculty of Medicine, İzmir, Turkey.
Purpose: To assess the contribution of intense neck ultrasonography (US) follow-up in the clinical management of differentiated thyroid carcinoma (DTC) patients with the American Thyroid Association (ATA) low-intermediate-risk of recurrence and an excellent response after total thyroidectomy and radioiodine therapy.
Materials And Methods: Medical records of patients who underwent serial follow-up neck US examinations between 1996 and 2022 were analyzed retrospectively. The utility of serial US examinations in detecting structural recurrence was assessed in all patients and different subgroups-categorized per the initial risk of recurrence and stimulated thyroglobulin (sTg) level at 1-year response assessment.
Predictive factors influencing hypothyroidism following the radioactive iodine treatment of Graves' disease in different periods.
Sci Rep
December 2024
Department of Nuclear Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
In China, due to the risks of hypothyroidism after radioiodine treatment, radioiodine is not commonly used as a first-line treatment. In this study, factors influencing the development of hypothyroidism after I therapy for Graves' hyperthyroidism were evaluated. This was a retrospective study with a 12-month follow-up.
View Article and Find Full Text PDFClinico-pathological factors and [F]FDG PET/CT metabolic parameters for prediction of progression-free survival in radioiodine refractory differentiated thyroid carcinoma.
BMC Med Imaging
December 2024
Department of Nuclear Medicine, Hospital 108, Hanoi, Vietnam.
Objective: Identifying prognostic markers for clinical outcomes is crucial in selecting appropriate treatment options for patients with radioiodine-refractory (RAI-R) differentiated thyroid carcinoma (DTC). The aim of this study was to investigate the prognostic value of clinico-pathological features and semiquantitative [F]FDG PET/CT metabolic parameters in predicting progression-free survival (PFS) in DTC patients with RAI-R.
Patients And Methods: This prospective cohort study included 110 consecutive RAI-R DTC patients who were referred for [F]FDG PET/CT imaging.
Iodine transfer to dairy cow's milk: A revised biokinetic model.
J Hazard Mater
December 2024
Faculty of Biosciences, Norwegian University of Life Sciences, PO Box 5003, Ås N-1432, Norway.
A new biokinetic model for iodine in dairy cows was developed utilizing data from a 4 × 4 factorial feeding experiment with rumen-cannulated cows that were fed rapeseed cake containing substances known to influence iodine metabolism, and soybean meal without such effects. I was administered both intravenously and intra-ruminally to document metabolism pathways. The new model included compartments such as saliva and thyroid gland, often ignored in other models, and in contrast to previously available biokinetic models, it fitted well to our experimental data.
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