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The association between the Glutathione S-transferase polymorphisms and addiction to opioids and methamphetamine in the Iranian population.
Front Psychiatry
December 2024
Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
Introduction: Glutathione S-transferase (GST) has the ability to detoxify the cellular environment of xenobiotic compounds and by-products of oxidative stress. The expression levels of GST genes and their polymorphisms are associated with various human diseases. Methamphetamine and opiate addiction also account for a significant proportion of SUDs in Iran.
View Article and Find Full Text PDFCrystal structures of two different multi-component crystals consisting of 1-(3,4-di-meth-oxy-benz-yl)-6,7-di-meth-oxy-iso-quinoline and fumaric acid.
Acta Crystallogr E Crystallogr Commun
October 2024
Two different multi-component crystals consisting of papaverine [1-(3,4-di-meth-oxy-benz-yl)-6,7-di-meth-oxy-iso-quinoline, CHNO] and fumaric acid [CHO] were obtained. Single-crystal X-ray structure analysis revealed that one, CHNO·1.5CHO (I), is a salt co-crystal composed of salt-forming and non-salt-forming mol-ecules, and the other, CHNO·0.
View Article and Find Full Text PDFClinical Efficacy of Intravenous Papaverine plus Ketorolac in the Emergency Treatment of Renal Colic: A Randomized, Double-blind Clinical Trial.
Iran J Med Sci
November 2024
Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Acute renal colic has been challenging and has brought many concerns for physicians and patients for centuries. This study aimed to evaluate the analgesic effect and safety of a combination of papaverine and ketorolac against ketorolac and placebo in treating acute renal colic.
Methods: This randomized clinical trial was performed in patients with renal colic from May 2018 to May 2020 in Ahvaz, Iran.
Symmetrical peripheral gangrene caused by urosepsis: Case reports and literature review.
Medicine (Baltimore)
October 2024
Department of Critical Care Medicine, Anqing Municipal Hospital, Anqing City, Anhui Provinces, China.
Rationale: Symmetrical peripheral gangrene (SPG) is a serious and rare complication in patients with urosepsis, characterized by distal limb symmetry impairment.
Patient Concerns: In this study, 3 cases of SPG caused by urosepsis were reported, and the Chinese and English literature on SPG caused by urosepsis was reviewed. The demographic, clinicopathological, treatment, and follow-up data of the patients were summarized and analyzed.
Is the phoenix sign phenomenon due to vasodilation? A double-blinded, randomized controlled trial comparing motor function recovery after diagnostic common fibular nerve block with lidocaine and papaverine.
BMC Musculoskelet Disord
October 2024
NE Wyoming Wound Care Clinic, Sheridan, WY, USA.
Article Synopsis
- Focal entrapment of the common fibular nerve (CFN) is a common issue in the lower body that can be hard to diagnose, with a temporary strengthening response known as the "Phoenix sign" sometimes observed after lidocaine blocks.
- A study involving 20 patients tested the effects of two vasodilating agents, lidocaine and papaverine, on improving muscle strength in the anterior compartment by measuring the extensor hallucis longus (EHL) muscle before and after treatment.
- Results showed that both agents produced significant improvements in muscle strength without notable differences between them, suggesting the Phoenix Effect is likely due to improved local blood circulation.
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