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In Vitro and In Vivo Anticancer Activities of Water-Soluble Ru(II)(η6--cymene) Complexes via Activating Apoptosis Central Regulators and Possibilities of New Antitumor Strategies in Triple Negative Breast Cancers.
J Med Chem
January 2025
Inner Mongolia Key Laboratory for Molecular Regulation of the Cell, Inner Mongolia University, Hohhot 010021, People's Republic of China.
In this study, we synthesized 12 monofunctional tridentate ONS-donor salicylaldimine ligand ()-based Ru(II) complexes with general formula [(Ru()(-cymene)]·Cl (-), characterized by H NMR, C NMR, UV, FT-IR spectroscopy, HR-ESI mass spectrometry, and single-crystal X-ray analysis showing ligand's orientation around the Ru(II) center. All 12 of these 12 complexes were tested for their anticancer activities in multiple cancer cells. The superior antitumor efficacy of , , and was demonstrated by reduced mitochondrial membrane potential, impaired proliferative capacity, and disrupted redox homeostasis, along with enhanced apoptosis through caspase-3 activation and downregulation of Bcl-2 expression.
View Article and Find Full Text PDFUtilising Free Middle Turbinate Mucosal Grafts to Reconstruct the Septal Donor Site Following Nasoseptal Flap Harvesting in Endoscopic Endonasal Approach for Sellar and Parasellar Lesions.
Clin Otolaryngol
January 2025
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Introduction: The nasoseptal flap (NSF) has become a widely favoured choice for reconstructing skull base defects following the endoscopic endonasal approach (EEA). However, the exposed septal cartilage and bone at the donor site often require an extended duration for secondary healing. This study investigated whether the free middle turbinate (MT) mucosa grafting at the septal donor site could mitigate post-operative nasal morbidity.
View Article and Find Full Text PDFDemography, Pleasure, State, and Market in Socialist Sexology: Medical-Sexological and Sexual-Psychological Public Discourse in Socialist Hungary Through Counseling Books From a Social-Political Perspective.
J Hist Behav Sci
January 2025
Department of Social Research Methodology, Eötvös Loránd University, Budapest, Hungary.
This paper analyzes medical-sexological and sexual-psychological public discourse in Hungary between the Second World War and the regime change, through counseling and science communication books. It engages with works on the history of Hungarian socialist sexual discourse. It differs from such works in two main respects.
View Article and Find Full Text PDFThe hemodialysis unit: the place where everybody knows your name.
Curr Opin Nephrol Hypertens
March 2025
Nephrology Division, NYU Langone Health, NYU Grossman School of Medicine, and New York Harbor VA Healthcare System, New York, New York, USA.
Loss and memorialization.
Int J Psychoanal
December 2024
Clinical Professor of Psychiatry, Weill Cornell Medical College, New York, USA; Editor Emeritus, The Psychoanalytic Quarterly.
Drawing upon Dana Birksted-Breen's work on temporality, and the contrast which she draws between linear, developmental time, seen as a series of unchanging moments, and bidirectional, process time, which is retranscribed again and again (Birksted-Breen [2003] 2016. "Time and the Apres-Coup." In , edited by D.
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