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CAR assembly line: Taking CAR T-cell manufacturing to the next level.
Best Pract Res Clin Haematol
December 2024
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
The widespread adoption of chimeric antigen receptor (CAR) T-cell therapy has been limited by complex, resource-intensive manufacturing processes. This review discusses the latest innovations aiming to improve and streamline CAR T-cell production across key steps like T-cell activation, genetic modification, expansion, and scaling. Promising techniques highlighted include generating CAR T cells from non-activated lymphocytes to retain a stem-like phenotype and function, non-viral gene transfer leveraging platforms like transposon and CRISPR, all-in-one fully automated bioreactors like the CliniMACS Prodigy and the Lonza Cocoon, rapid CAR T-cell manufacturing via abbreviating or eliminating ex vivo T-cell culture, implementing decentralized point-of-care automated manufacturing platforms, and optimizing centralized bioreactor infrastructure integrating end-to-end automation.
View Article and Find Full Text PDFAssociation Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm.
J Am Coll Cardiol
March 2025
Ciccarone Center for Prevention of Cardiovascular Disease, Johns Hopkins Medicine, Baltimore, Maryland, USA; American Heart Association Tobacco Regulation and Addiction Center, Dallas, Texas, USA. Electronic address:
Background: Cigarette smoking is a strong risk factor for cardiovascular harm.
Objectives: The study sought to explore the detailed relationships between smoking intensity, pack-years, and time since cessation with inflammation, thrombosis, and subclinical atherosclerosis markers of cardiovascular harm.
Methods: We included 182,364 participants (mean age 58.
Expression and localization of HBsAg in corneas from HBsAgseropositive donors preserved in mediumterm preservation solution and glycerol.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: Due to the severe shortage of donor corneas for transplantation in China, corneal component transplantation may expand the available donor pool. This study aims to evaluate the safety and feasibility of corneal component transplantation by examining the distribution of hepatitis B surface antigen (HBsAg) in corneas from HBsAg-seropositive donors under different storage media.
Methods: Ten corneas (from 6 donors) donated between December 2019 and March 2021 and stored at the Eye Bank of Xiangya Third Hospital, Central South University, were analyzed.
Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes.
J Immunol
January 2025
Center for Translational Immunology, Benaroya Research Institute, Seattle, WA, United States.
The CD2-depleting drug alefacept (LFA3-Ig) preserved beta cell function in new-onset type 1 diabetes (T1D) patients. The most promising biomarkers of response were late expansion of exhausted CD8 T cells and rare baseline inflammatory islet-reactive CD4 T cells, neither of which can be used to measure responses to drug in the weeks after treatment. Thus, we investigated whether early changes in T cell immunophenotypes could serve as biomarkers of drug activity.
View Article and Find Full Text PDFWhat is the value of testing for tick-borne diseases in cattle in endemic areas? A case study of bovine anaplasmosis.
PLoS One
March 2025
Instituto de Investigación en Zoonosis (CIZ), Universidad Central del Ecuador, Quito, Ecuador.
Anaplasmosis is a tick-borne disease (TBDs) caused by Anaplasma spp. In areas where TBDs are endemic, it is crucial to consider the animals' immunological status in relation to these diseases. The true prevalence of bovine anaplasmosis, the percentage of animals with protective antibodies against this TBD, and the diagnostic characteristics of three tests (multiplex polymerase chain reaction (mPCR), competitive-inhibition enzyme-linked immunosorbent assay (cELISA), and blood smear (BS)) were estimated using a Bayesian approach.
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