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Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele.
bioRxiv
November 2024
Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Common intronic enhancer SNPs in Shroom3 associate with CKD in GWAS, although there is paucity of detailed mechanism. Previously, we reported a role for Shroom3 in mediating crosstalk between TGFβ1- & Wnt/Ctnnb1 pathways promoting renal fibrosis (TIF). However, beneficial roles for Shroom3 in proteinuria have also been reported suggesting pleiotropic effects.
View Article and Find Full Text PDFRetrospective evaluation of risk factors for worsening renal function after angiotensin-converting enzyme inhibitor treatment in dogs.
J Vet Intern Med
December 2024
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Article Synopsis
- ACE inhibitors (ACEi) can worsen kidney function in dogs, so it's important to recheck renal function within 1-2 weeks after starting treatment.
- A study analyzed 156 dogs on ACEi to identify risk factors for worsening renal function (WRF), finding that 17% experienced WRF, which was mostly mild to moderate.
- The main risk factors for WRF were concurrent use of furosemide and pre-existing kidney issues (azotemia), highlighting the need for cautious use of ACEi in these cases.
The clinical efficacy of cGMP-specific sildenafil on mitochondrial biogenesis induction and renal damage in cats with acute on chronic kidney disease.
BMC Vet Res
October 2024
Faculty of Veterinary Medicine, Department of Internal Medicine, Selcuk University, Konya, 42250, Türkiye.
Background: Mitochondrial biogenesis (MB) induction has recently emerged as potential therapeutic approaches in kidney pathology and the mitochondria-targeted therapies should be investigated to improve treatment of animals with kidney diseases. This study aimed to investigate the effects of MB induction with sildenafil citrate on the cGMP/NO pathway, glomerular filtration, and reduction of kidney damage and fibrosis (TGF-β/SMAD pathway) in cats with acute on chronic kidney disease (ACKD). Thirty-three cats were divided into the non-azotemic (healthy) group (n:8) and the ACKD group (n:25), comprising different breeds, sexes, and ages.
View Article and Find Full Text PDFEffect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary-Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats.
Animals (Basel)
September 2024
Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, Germany.
Article Synopsis
- Radioiodine therapy (RAIT) is the preferred treatment for hyperthyroidism in cats, and this study focused on how the presence of thyroid adenoma affects hormone and creatinine levels after treatment.
- A total of 51 hyperthyroid cats were monitored over 6 to 12 months, measuring total thyroxine (TT4), thyroid-stimulating hormone (TSH), and creatinine levels at various intervals after RAIT.
- Results showed that cats with bilateral adenoma had higher TSH levels post-treatment, TT4 levels dropped significantly within a month, and while creatinine levels initially remained stable, some cats showed later increases, indicating that monitoring for potential hypothyroidism should continue for at least 6 to
Functional Foods and Adapted Physical Activity as New Adjuvant Therapy for Chronic Kidney Disease Patients.
Nutrients
July 2024
Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Article Synopsis
- Chronic kidney disease (CKD) is projected to be a leading cause of death by 2040, highlighting the need for effective prevention and treatment strategies to lower healthcare costs.
- The study evaluated the impact of a 12-week intervention combining functional foods (FFs) and adapted physical activity (APA) on 40 CKD patients, compared to those receiving standard care.
- Results showed significant health improvements in the combined group, including reduced blood pressure and inflammation, increased muscle mass, and overall better quality of life for CKD patients.
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