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The impact of 3-sulfo-taurolithocholic acid on ATPase activity in patients' colorectal cancer and normal colon tissues, and its hepatic effects in rodents.
Front Vet Sci
December 2024
Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czechia.
Colorectal cancer is influenced by genetic mutations, lifestyle factors, and diet, particularly high fat intake, which raises bile acid levels in the intestinal lumen. This study hypothesized that bile acids contribute to tumorigenesis by disrupting ion transport and ATPase activity in the intestinal mucosa. The effects of 3-sulfo-taurolithocholic acid (TLC-S) on ATPase activity were investigated in colorectal cancer samples from 10 patients, using adjacent healthy tissue as controls, and in rodent liver function.
View Article and Find Full Text PDFEvaluation of carp sperm respiration: fluorometry with optochemical oxygen sensor versus polarography.
Fish Physiol Biochem
February 2025
South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in České Budějovice, Zátiší 728/II, 389 25, Vodňany, Czech Republic.
The primary function of spermatozoa is to fertilize the oocyte, which depends on their motility and is directly associated with their metabolic state. The oxygen consumption rate (OCR) of spermatozoa reflects the respiratory capacity of sperm mitochondria under various physiological conditions and is an essential marker of sperm quality. We determined the OCR of common carp (Cyprinus carpio) sperm using two respirometry methods: the conventionally used polarographic method with a Clark-type electrode and fluorometric assay with an Oxo Dish optochemical oxygen sensor.
View Article and Find Full Text PDFObjective: Aim: To identify appropriate methods for determining the content of radioactive and non-radioactive pulmotoxic xenobiotics in the ambient air of NPP equipment to ensure its reliability, radiation and environmental safety, as well as to reduce the risks of occupational pathologies for workers and protect people's health.
Patients And Methods: Materials and Methods: Analytical methods of analysis of modern methods of determining the content of radioactive and non-radioactive pulmonary toxic xenobiotics in the ambient air of NPP equipment.
Conclusion: Conclusions: a) during operation of NPP equipment, pulmotoxic xenobiotics enter the surrounding air, which can then enter the human respiratory system in the form of radioactive or non-radioactive substances; b) signif i cant methods of determining the content of pulmotoxic xenobiotics in the air are: gas chroma-tography; gas chromatography-mass spectrometry; liquid scintillation; photometric, ionometric, polarographic, titrometric, turbidimetric, atomic absorption, radiometric and γ-spectrometric measurements; c) radioactive pulmonotoxic xenobiotics cause radiation pathologies in the respiratory organs as a result of internal radioactive irradiation of the body; d) the effects of non-radioactive pulmotoxic xenobiotics are accompanied by irritation and inf l ammatory processes in the respiratory organs, as well as toxic swelling of the lungs; е) there is a connection between the presence of pulmotoxic xenobiotics in the air and the course of human respiratory diseases as a result of breathing such air.
Implications of the partial volume effect correction on the spatial quantification of hypoxia based on [F]FMISO PET/CT data.
Phys Med
December 2024
Division of Medical Physics, Department of Radiation Oncology, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), partner site DKTK-Freiburg, Germany.
Article Synopsis
- This study analyzes how correcting the partial volume effect (PVE) in PET imaging improves the accuracy of measuring tumor hypoxia, specifically using FMISO PET images from head and neck cancer patients.
- The researchers found that PVE correction increased the calculated hypoxic tumor volume (HTV) and provided better alignment of oxygen pressure measurements with established data.
- They concluded that PVE correction is crucial for accurately quantifying tumor hypoxia, as it significantly impacts the assessment of treatment strategies and outcomes.
The impact of cannabinoid receptor 1 absence on mouse liver mitochondria homeostasis: insight into mitochondrial unfolded protein response.
Front Cell Dev Biol
October 2024
Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Caserta, Italy.
Introduction: The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compartment in the liver, focusing on both functional aspects and remodeling processes.
Methods: We used CB1 and CB1 male mice.
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