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Developing a method for the study of perfusion effects in topical product pharmacokinetics.
Eur J Pharm Sci
February 2025
Wellman Center for Photomedicine, Massachusetts General Hospital, 149 13th St, Charlestown, 02129, MA, USA. Electronic address:
Article Synopsis
- Topical drug products are used to treat skin diseases but their pharmacokinetics are hard to study in live environments due to skin's complex barrier and lack of assessment methods.
- This study introduces a new method using stimulated Raman scattering (SRS) microscopy to analyze how blood flow (perfusion) affects the uptake of the drug tazarotene in mice.
- Results showed that perfusion increased tazarotene absorption in lipid-rich areas of the skin, while in non-perfused (ex vivo) conditions, the drug uptake was significantly slower, highlighting the importance of blood flow in drug delivery.
Expanding the cytological and architectural spectrum of mucoepidermoid carcinoma: The key to solving diagnostic problems in morphological variants.
Semin Diagn Pathol
July 2024
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Varying sized cysts and sheets composed of three cell types (epidermoid, intermediate, and mucous cells) with varying degrees of atypia form the characteristic histological appearance of MEC. MEC frequently contains a wide variety of modified tumor cells and can be entirely cystic or completely solid.
View Article and Find Full Text PDFMosaic RASopathies concept: different skin lesions, same systemic manifestations?
J Med Genet
April 2024
Division of Genetic Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Background: Cutaneous epidermal nevi are genotypically diverse mosaic disorders. Pathogenic hotspot variants in , , and less frequently and may cause isolated keratinocytic epidermal nevi and sebaceous nevi or several different syndromes when associated with extracutaneous anomalies. Therefore, some authors suggest the concept of mosaic RASopathies to group these different disorders.
View Article and Find Full Text PDFA review of sebum in mammals in relation to skin diseases, skin function, and the skin microbiome.
PeerJ
December 2023
Department of Environmental and Life Sciences, Trent University, Peterborough, Ontario, Canada.
Diseases vary among and within species but the causes of this variation can be unclear. Immune responses are an important driver of disease variation, but mechanisms on how the body resists pathogen establishment before activation of immune responses are understudied. Skin surfaces of mammals are the first line of defense against abiotic stressors and pathogens, and skin attributes such as pH, microbiomes, and lipids influence disease outcomes.
View Article and Find Full Text PDFCross-Sectional Assessment of Dermatologists' Knowledge and Attitude Towards Isotretinoin-Related Ocular Side Effects in Aseer, Saudi Arabia.
Cureus
October 2023
Medicine, College of Medicine, King Khalid University, Abha, SAU.
Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, which includes the hair follicle, hair shaft and sebaceous gland. The only treatment that has an effect on all the main aetiological causes of acne is isotretinoin. However, it may have a variety of negative side effects.
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