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Catecholestrogens excretion in smoking and non-smoking postmenopausal women receiving estrogen replacement therapy.
J Steroid Biochem Mol Biol
March 2000
Laboratory Oncoendocrinology, Prof. N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
Estrogens are involved in the etiology of breast cancer. Their blastomogenic influence may be partly realized through their conversion into catecholestrogens, rate of which may be modified by smoking. The risk of having breast cancer diagnosed can increase in women using estrogen replacement therapy (ERT).
View Article and Find Full Text PDFThis paper presents a critical review more than 100 references on the possible leukomogenic (blastomogenic) effects of benzene, based upon clinical, epidemiological and experimental dates. The authors came to conclusion that there exist reliable clinical and epidemiological evidences, concerning increased leukomogenic risk on working place with high benzene concentrations in past years (tens and even hundreds of ppm). Most epidemiological studies, indicate now that this risk is also elevated in more favourable working conditions, although practical valuable dose-effect relationship between benzene concentrations and rate of leukomogenic risks is still unknown.
View Article and Find Full Text PDFMongrel guinea pigs were given 3-indolilacrilacid and 2-aminoacetophenon derivates of tryptophan which blastomogenic action was previously revealed in experiments on inbred mice. Both substances produced tumors in animals of the experimental groups earlier than in the control group, this fact showing both the preparations to have blastomogenic effect. The results of the investigation show the possibility of using guinea pigs for studying the blastomogenic action of weak cancerogenic agents to which the endogenic blastomogenic substances belong.
View Article and Find Full Text PDFThe character of blastomogenic action of 7,12-dimethylbenz(a)anthracene on the stomach in its parenteral administration was studied on different lines of mice. Under the same conditions DMBA distribution was investigated in the proventriculus and gastric glandular tissues. In DMBA application on mice skin in the dosage of 0.
View Article and Find Full Text PDFThe character of blastomogenic action of 7,12-dimethylbenz(a)anthracene on the stomach in its parenteral administration was studied on different lines of mice. Under the same conditions DMBA distribution was investigated in the proventriculus and gastric glandular tissues. In DMBA application on mice skin oin the dosage of 0.
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