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Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway.
Microb Biotechnol
January 2025
Huadong Medical Institute of Biotechniques, Nanjing, China.
Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in liver diseases. Disulfiram (DSF) is a multitarget drug that has been proven to play a role in a variety of liver diseases and can affect intestinal flora, but whether it can alleviate ALI is not clear.
View Article and Find Full Text PDFThe Role of 418 Gut Microbiota in Small Cell Lung Cancer Progression: A Mendelian Randomisation Study.
J Coll Physicians Surg Pak
January 2025
Department of Radiotherapy, Binhai County People's Hospital, Yancheng, Jiangsu, China.
Objective: To investigate the causal influence of gut microbiota on small cell lung cancer (SCLC) progression using Mendelian randomisation (MR), providing insights into the gut-lung axis in lung cancer pathology.
Study Design: Analytical study. Place and Duration of the Study: Department of Radiotherapy, Binhai County People's Hospital, Yancheng, Jiangsu, China, and Department of Paediatrics, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China, from January to May 2024.
Investigation of the physicochemical factors affecting the in vitro digestion and glycemic indices of indigenous indica rice cultivars.
Sci Rep
January 2025
Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Rice (Oryza sativa) is a vital food crop and staple diet for most of the world's population. Poor dietary choices have had a significant role in the development of type-2 diabetes in the population that relies on rice and rice-starch-based foods. Hence, our study investigated the in vitro digestion and glycemic indices of certain indigenous rice cultivars and the factors influencing these indices.
View Article and Find Full Text PDFMultidimensional profiling of cancer microenvironments in FFPE tissues by imaging mass cytometry.
Methods Cell Biol
January 2025
Pathology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
In recent years, significant advancements have been achieved in the development of multiplex imaging methodologies for immunophenotyping, enabling a comprehensive characterization of the complexity of tumor microenvironments. Imaging mass cytometry combines the detection of over 40 cellular targets with spatial information, enabling the identification of not only which cells are present in a tissue but also their localization relative to each other. Here, we present an easy-to-implement imaging mass cytometry workflow that ranges from antibody selection and testing to running a full panel.
View Article and Find Full Text PDFAlginate-based materials as adsorbent for sustainable water treatment.
Int J Biol Macromol
January 2025
Centre for Advanced Composite Materials, Universiti Teknologi Malaysia (UTM), Johor Bahru 81310, Malaysia.
With the encroaching issue of water pollution, the use of involved chemicals to remove pollutants from water is not only a risk of chemical contamination, a potential hazard to the environment and human health but also requires significant investment in managing and improving the chemicals. Therefore, alginate as one of the nanomaterial-adorned polysaccharides-based entity that usually extract from brown algae has been used as novel and more efficient catalysts in the removal of a variety of aqueous pollutants from wastewater, including ionic metals and organic/inorganic pollutants by using the adsorption techniques. Adsorption is a technique used in water treatment where non-polar or particles less soluble in water are stuck to the surface of the adsorbent and therefore purifying it.
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