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Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective.
Nat Commun
January 2025
Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
The standard dengue virus (DENV) neutralization assay inconsistently predicts dengue protection. We compare how IgG ELISA, envelope domain III (EDIII), or non-structural protein 1 (NS1) binding antibodies, and titers from plaque reduction neutralization tests (PRNTs) using standard and mature viruses are associated with dengue. The ELISA measures IgG antibodies that bind to inactivated DENV1-4.
View Article and Find Full Text PDFThe N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells.
Front Microbiol
December 2024
ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.
Article Synopsis
- Type 1 diabetes (T1D) results from an autoimmune attack that destroys insulin-producing beta cells, with its initiation linked to genetic, immunological, and environmental factors, particularly viral infections like Coxsackievirus B (CVB).
- Research reveals that CVB serotype 1 (CVB1) may trigger autoimmune responses in genetically susceptible individuals, but the exact mechanisms of its replication in beta cells are unclear.
- New findings indicate that the N6-methyladenosine (m6A) modification influences CVB1 amplification, where downregulating m6A "writers" increases viral replication, while inhibiting "erasers" like FTO significantly decreases infectious CVB1 production, highlighting m6A's role
Genomic analysis of isolated from surface water and animal sources in Chile reveals new T6SS effector protein candidates.
Front Microbiol
December 2024
Núcleo de Investigación en One Health, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Santiago, Chile.
Type VI Secretion Systems (T6SS), widely distributed in Gram-negative bacteria, contribute to interbacterial competition and pathogenesis through the translocation of effector proteins to target cells. harbor 5 pathogenicity islands encoding T6SS (SPI-6, SPI-19, SPI-20, SPI-21 and SPI-22), in which a limited number of effector proteins have been identified. Previous analyses by our group focused on the identification of candidate T6SS effectors and cognate immunity proteins in genomes deposited in public databases.
View Article and Find Full Text PDFPrevalence and transmission of Salmonella collected from farming to egg processing of layer production chain in Jiangsu Province, China.
Poult Sci
December 2024
Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225009, PR China. Electronic address:
Salmonella is a common foodborne pathogen found in poultry production systems. Contaminated poultry products are a major source of human salmonellosis. Understanding the conditions of contamination and the genetic relationships of Salmonella in poultry production is necessary to develop effective interventions measures for controlling Salmonella transmission.
View Article and Find Full Text PDFResearch note: Prevalence and genetic characteristics of pathogenic E. coli isolates from domestic pigeons in central China.
Poult Sci
December 2024
Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China. Electronic address:
Pigeon has become popular as a food recently, due to their highly nutritive valuE. colibacillosis, which is caused by pathogenic E. coli, is one of the most important bacterial diseases in pigeon breeding.
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