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Renal nerves and hypertension contribute to impaired proximal tubule megalin-mediated albumin uptake in renovascular hypertensive rats.
Hypertens Res
January 2025
Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Proteinuria, especially albuminuria, serves as an independent risk factor for progression in cardiovascular and renal diseases. Clinical and experimental studies have demonstrated that renal nerves contribute to renal dysfunction in arterial hypertension (AH). This study hypothesizes that renal nerves mediate the mechanisms of protein endocytosis by proximal tubule epithelial cells (PTEC) and glomerular function; with dysregulation of the renal nerves contributing to proteinuria in Wistar rats with renovascular hypertension (2-kidney, 1-clip model, 2K-1C).
View Article and Find Full Text PDFPreliminary Characterization of the Vasorelaxant Effect of Thymus atlanticus (Ball) Roussine Using Optical Methods.
Curr Drug Discov Technol
November 2024
Biochemistry of Natural Ressources Team, Faculty of sciences and Techniques, Errachidia, University Moulay Ismail, Meknes, Morocco.
Background: Thymus atlanticus (Ball) Roussine is a Moroccan endemic thyme species that is traditionally used as an aromatic and medicinal plant. Several studies have demonstrated its pharmacological significance and therapeutic value.
Objective: The current study aimed to assess the vasorelaxant effect of the aqueous extract of this species.
Discovering novel targets of abscisic acid using computational approaches.
Comput Biol Chem
October 2024
Department of Biology, Shahid Bahonar University of Kerman, Kerman, Iran.
Abscisic acid (ABA) is a crucial plant hormone that is naturally produced in various mammalian tissues and holds significant potential as a therapeutic molecule in humans. ABA is selected for this study due to its known roles in essential human metabolic processes, such as glucose homeostasis, immune responses, cardiovascular system, and inflammation regulation. Despite its known importance, the molecular mechanism underlying ABA's action remain largely unexplored.
View Article and Find Full Text PDFHigh sodium, rather than high blood pressure, induces immune cell activation and renal infiltration in ovariectomized adult Wistar rats.
Biochem Biophys Res Commun
August 2024
Universidad de Buenos Aires, Instituto de Investigaciones Médicas A. Lanari, Laboratorio de Nefrología Experimental y Bioquímica Molecular, Combatientes de Malvinas 3150, Buenos Aires, 1427, Argentina; Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Investigaciones Médicas A. Lanari, Combatientes de Malvinas 3150, Buenos Aires, 1427, Argentina; Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Médicas, Departamento de Ciencias Fisiológicas. Instituto de Fisiología y Biofísica B. Houssay (IFIBIO-Houssay), Laboratorio de Fisiología Renal, Paraguay 2155, piso 4, Buenos Aires, 1121, Argentina. Electronic address:
We used an animal model of salt-sensitive hypertension (SSH) in which ovariectomized (oVx) rats developed hypertension with high salt (HS) intake. Hypertension is accompanied by changes in the percentage of CD4 T lymphocytes, immune CD45 cell infiltration into renal tissue, and changes in Na, K- ATPase (NKA) expression in both renal tissue and peripheral blood mononuclear cells (PBMCs). To determine whether the observed changes resulted from HS intake, high blood pressure, or both, hydralazine (HDZ) was used to lower blood pressure.
View Article and Find Full Text PDFArticle Synopsis
- Hypertension and sudden spikes in blood pressure are linked to aortic dissection, especially in older patients or those with connective tissue disorders.
- In experiments with adult mice, the presence of norepinephrine increased blood pressure and triggered aortic dissection, which was alleviated by the vasodilator hydralazine.
- The study found that the underlying problem was not in regulatory molecules but in the production of extracellular matrix, leading to a weakened aorta due to reduced collagen, making it more susceptible to dissection.
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