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A Highly Bioactive Organic-Inorganic Nanoparticle for Activating Wnt10b Mediated Osteogenesis by Specifically Anchor CCN3 Protein.
Adv Healthc Mater
January 2025
Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, P. R. China.
The rapid and efficient bone regeneration is still in unsatisfactory outcomes, demonstrating alternative strategy and molecular mechanism is necessary. Nanoscale biomaterials have shown some promising results in enhancing bone regeneration, however, the detailed interaction mechanism between nanomaterial and cells/tissue formation is not clear. Herein, a molecular-based inorganic-organic nanomaterial poly(citrate-siloxane) (PCS) is reported which can rapidly enhance osteogenic differentiation and bone formation through a special interaction with the cellular surface communication network factor 3 (CCN3), further activating the Wnt10b/β-catenin signaling pathway.
View Article and Find Full Text PDFIn Situ Anchoring Functional Molecules to Polymer Chains Through Supramolecular Interactions for a Robust and Self-Healing Multifunctional Waterborne Polyurethane.
Small
January 2025
Department of Polymer Materials and Engineering, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, P. R. China.
Nowadays, much attention is paid to the development of high-performance and multifunctional materials, but it is still a great challenge to obtain polymer materials with high mechanical properties, high self-healing properties, and multifunctionality in one. Herein, an innovative strategy is proposed to obtain a satisfactory waterborne polyurethane (PMWPU-Bx) by in situ anchoring 3-aminophenylboronic acid (3-APBA) in a pyrene-capped waterborne polyurethane (PMWPU) via supramolecular interactions. The multiple functional sites inherent in 3-APBA can produce supramolecular interactions with groups on PMWPU, promoting the aggregation of hard domains in the polymer network, which confers the PMWPU-Bx strength (7.
View Article and Find Full Text PDFLentinan-functionalized PBAE-G-nanodiamonds as an adjuvant to induce cGAS-STING pathway-mediated macrophage activation and immune enhancement.
J Pharm Anal
December 2024
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450045, China.
A series of biodegradable nanoparticle-based drug delivery systems have been designed utilizing poly(β-amino ester)-guanidine-phenylboronic acid (PBAE-G) polymers. In this study, a novel Lentinan-Functionalized PBAE-G-nanodiamond system was developed to carry ovalbumin (LNT-PBAE-G-ND@OVA). The impact of this drug delivery system on the activation and maturation of macrophages was then assessed.
View Article and Find Full Text PDFLoss or inhibition of lysosomal acid lipase leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function.
BBA Adv
December 2024
Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Skeletal muscle (SM) is essential for movement, stability, and overall body function, and it readily adapts to changes in energy demand. Myogenesis is energy-intensive and involves complex molecular and cellular events. We recently demonstrated that the absence of lysosomal acid lipase (LAL) significantly impacts the SM phenotype, primarily by disrupting energy homeostasis and reducing ATP production.
View Article and Find Full Text PDFNAFPD exacerbation by hyperlipidemia combined with hyperuricemia: a pilot rat experiment in lipidomics.
Front Nutr
January 2025
Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Background: Hyperuricemia and non-alcoholic fatty pancreas disease (NAFPD) are prevalent metabolic diseases, but the relationship between them remains underexplored.
Methods: Eighteen Sprague-Dawley rats were randomly assigned to three groups: normal (CON), high-fat (PO), and high-fat high-uric acid (PH). After 12 weeks, serum uric acid (SUA) and triacylglycerol levels were measured.
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