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Symptomatic Vasospasm Refractory to Clazosentan after Subarachnoid Hemorrhage of Ruptured Vertebral Artery Dissecting Aneurysm: Clinical Implications from Two Contrasting Cases.
Medicina (Kaunas)
September 2024
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels, Akita Cerebrospinal and Cardiovascular Center, Akita 010-0874, Japan.
Clazosentan prevents vasospasms after aneurysmal subarachnoid hemorrhage (SAH). However, clinical data on patients with SAH with ruptured vertebral artery dissecting aneurysms (VADAs) are limited. We report the case of a 49-year-old male patient with mild-grade (WFNS grade 1) thick and diffuse (modified Fisher grade 3) SAH who underwent endovascular trapping of a ruptured VADA, resulting in a poor functional outcome with a modified Rankin Scale score of 4 due to severe symptomatic vasospasm refractory to clazosentan, requiring repeated rescue endovascular therapies and chronic communicating hydrocephalus.
View Article and Find Full Text PDFFibrinogen and plasma clot properties are associated with apolipoprotein B and apolipoprotein B-containing lipoproteins in Africans.
J Clin Lipidol
August 2024
Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa (Drs Bruwer, de Lange-Loots and Pieters); SAMRC Extramural Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa (Drs de Lange-Loots and Pieters). Electronic address:
Background: Case-control, intervention and laboratory studies have demonstrated a link between apolipoprotein B-containing lipoproteins and clot structure and thrombosis. There is, however, limited evidence on population level.
Objectives: We determined the cross-sectional relationship between lipoprotein(a) (Lp(a)), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (ApoB) with fibrinogen and plasma clot properties in 1 462 Black South Africans, a population with higher fibrinogen and Lp(a) levels compared with individuals of European descent.
Fibrinolysis is impaired in patients with primary immune thrombocytopenia.
J Thromb Haemost
November 2024
Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria. Electronic address:
Article Synopsis
- * In a study of 86 ITP patients and 78 healthy controls, findings showed that ITP patients had significantly slower clot lysis times and higher levels of plasminogen activator inhibitor-1 (PAI-1), while tissue plasminogen activator (tPA) levels were lower.
- * The results suggest that prolonged clot lysis time (CLT) and altered fibrinolysis mechanisms in ITP may contribute to thrombosis risk, with specifically higher tPA-PAI-1 complexes indicating potential
Complement activation is associated with right ventricular dysfunction and the severity of pulmonary embolism: links with prothrombotic state.
J Thorac Dis
May 2024
Department of Thromboembolic Diseases, Institute of Cardiology, Jagiellonian University Medical College, St. John Paul II Hospital, Krakow, Poland.
Background: Little is known about the role of complement activation in acute pulmonary embolism (PE). We investigated whether complement activation is associated with the severity of acute PE, along with the associated prothrombotic state, systemic inflammation and neutrophil extracellular traps (NETs) formation.
Methods: We studied 109 normotensive, non-cancer PE patients (aged 58.
Blood clot properties, thrombin generation, and platelet activation in patients with dysglycemia and established atherosclerotic cardiovascular disease: The CASCARA study.
Kardiol Pol
July 2024
Department of Coronary Artery Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland.
Background: There is a strong link between coronary artery disease (CAD), type 2 diabetes (T2D) on one hand, and altered fibrin clot properties, including increased clot density, and unfavorable fibrin clot structure on the other. T2D-related changes in fibrin clots can increase cardiovascular (CV) disease risk, including future CV events. We aimed to assess fibrin clot properties, thrombin generation, and platelet activation in CAD patients with prediabetes (PD) or T2D, compared to CAD patients without glycemic disorders.
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