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Cardioneuroablation for reflex syncope or functional bradyarrhytmias: new insight from a single center experience.
Front Cardiovasc Med
January 2025
Department of Cardiology, General Regional Hospital "F. Miulli", Bari, Italy.
Background: Cardioneuroablation (CNA) is a new approach to treat reflex syncope and functional bradyarrhytmias caused by autonomic imbalance. We report our experience using CNA.
Method: From September 2022 to July 2023, we took care of 21 patients (mean age 42 ± 21 years; 62% male) affected by reflex syncope or functional bradyarrhythmias.
Asymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.
J Comp Neurol
January 2025
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Direction selectivity is a fundamental feature in the visual system. In the retina, direction selectivity is independently computed by ON and OFF circuits. However, the advantages of extracting directional information from these two independent circuits are unclear.
View Article and Find Full Text PDFReducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain.
Brain Behav Immun
January 2025
Laboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:
Preclinical and clinical studies have established that autoreactive immunoglobulin G (IgG) can drive neuropathic pain. We recently demonstrated that sciatic nerve chronic constriction injury (CCI) in male and female mice results in the production of pronociceptive IgG, which accumulates around the lumbar region, including within the dorsal root ganglia (DRG) and spinal cord, facilitating the development of neuropathic pain. These data raise the intriguing possibility that neuropathic pain may be alleviated by reducing the accumulation of IgG.
View Article and Find Full Text PDFArtificial intelligence assisted virtual reality training module for Gasserian ganglion block.
Interv Pain Med
March 2025
Department of Anesthesiology, Perioperative, and Pain Medicine, Weill Cornell Medicine, New York, NY, USA.
•: The AI-assisted VR module enables learners to engage in a 360-degree immersive environment, manipulating holographic anatomy models and simulating fluoroscopic guidance to perform the Gasserian ganglion block.•: Key anatomical landmarks, like the foramen ovale, are highlighted, and proper C-arm positioning is demonstrated, helping practitioners localize the target area for needle advancement.•: The module includes AI-driven multi-language options and AI-generated multiple-choice questions to enhance learning and retention.
View Article and Find Full Text PDFDelta opioid receptors affect acoustic features of song during vocal learning in zebra finches.
BMC Neurosci
January 2025
National Brain Research Centre, Manesar, Gurugram, 122052, Haryana, India.
Delta-opioid receptors (δ-ORs) are known to be involved in associative learning and modulating motivational states. We wanted to study if they were also involved in naturally-occurring reinforcement learning behaviors such as vocal learning, using the zebra finch model system. Zebra finches learn to vocalize early in development and song learning in males is affected by factors such as the social environment and internal reward, both of which are modulated by endogenous opioids.
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