A rabbit model for coronavirus-induced dilated cardiomyopathy is described. Acute rabbit coronavirus infection results in virus-induced myocarditis and congestive heart failure. Of the survivors of rabbit coronavirus infection, 41% had increased heart weight and heart weight-to-body weight ratios, biventricular dilation, myocyte hypertrophy, myocardial fibrosis, and myocarditis consistent with the development of dilated cardiomyopathy. These changes were also seen in the remaining 59% of the survivors, except that the degree of myocyte hypertrophy was reduced and only right ventricular dilation was present. In most survivors, myocarditis was usually mild (1-5 foci/transverse section), but in some cases it was severe (> 20 foci/transverse section). Interstitial and replacement fibrosis was more pronounced in the papillary muscles. These data suggest that rabbit coronavirus infection may progress to dilated cardiomyopathy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109931 | PMC |
| http://dx.doi.org/10.1093/infdis/166.5.978 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aetiology and clinical manifestations of patients with non-dilated left ventricular cardiomyopathy. Some comments.
Eur J Heart Fail
January 2025
Department of Engineering for Innovation Medicine, Faculty of Medicine and Surgery, University of Verona, Verona, Italy.
Therapeutic Dilemmas Arising From a Serpentine Thrombus Across a Patent Foramen Ovale in a Patient With Dilated Cardiomyopathy.
Cureus
December 2024
Cardiology/Internal Medicine, Luton and Dunstable University Hospital, Luton, GBR.
A thrombus straddling a patent foramen ovale (TSPFO) is a rare condition that presents significant health risks, including stroke or myocardial infarction, and can be life-threatening if not promptly addressed. We report the case of a 42-year-old female with morbid obesity who presented with sudden shortness of breath due to a bilateral pulmonary embolism. Imaging revealed a thrombus extending from the right atrium to the left atrium through the patent foramen ovale (PFO).
View Article and Find Full Text PDFAtypical Presentation of Andersen-Tawil Syndrome: Heart Failure with Reduced Ejection without Periodic Paralysis or Dysmorphic Features.
Eur J Case Rep Intern Med
December 2024
Internal Medicine, Holy Family Hospital, Rawalpindi, Pakistan.
Background: Andersen-Tawil syndrome (ATS) is a rare autosomal dominant disorder caused by variants in the gene. It is associated with periodic paralysis, dysmorphic features and cardiac arrhythmias. The syndrome exhibits incomplete penetrance, leading to a broad spectrum of clinical manifestations, making diagnosis challenging.
View Article and Find Full Text PDFPreoperative Computed Tomography Virtual Simulation for HeartMate 3 Implantation in Small Children.
Ann Thorac Surg Short Rep
September 2024
Department of Cardiovascular Surgery, Tokyo Women's Medical University, The Heart Institute of Japan, Tokyo, Japan.
An implantable ventricular assist device became smaller and has been used for small body size patients. However, it is still challenging to determine whether it is implantable for pediatric patients. The preoperative computed tomography virtual simulation provided spatial information among the pump, intracardiac structures, and extracardiac structures, which was very useful to assess the implantability for borderline children.
View Article and Find Full Text PDFChallenges in clinical translation of cardiac magnetic resonance imaging radiomics in non-ischemic cardiomyopathy: a narrative review.
Cardiovasc Diagn Ther
December 2024
The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China, Hengyang, China.
Background And Objective: Radiomics is an emerging technology that facilitates the quantitative analysis of multi-modal cardiac magnetic resonance imaging (MRI). This study aims to introduce a standardized workflow for applying radiomics to non-ischemic cardiomyopathies, enabling clinicians to comprehensively understand and implement this technology in clinical practice.
Methods: A computerized literature search (up to August 1, 2024) was conducted using PubMed to identify relevant studies on the roles and workflows of radiomics in non-ischemic cardiomyopathy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!