AI Article Synopsis
- Antigenic regions of the human cytomegalovirus (CMV pp150) were found that trigger immune responses in patients with active infections and in those who are seropositive.
- A significant portion (8.3% to 61.6%) of healthy seropositive blood donors tested positive for single peptides, while 91.6% reacted to a combination of four peptides.
- Patients showing active CMV infection displayed specific antibody responses to certain peptide regions, and those with primary infections showed different reactivity patterns compared to those with reactivated infections.
Article Abstract
We have identified antigenic regions within phosphoprotein 150 of human cytomegalovirus (CMV pp150) to which seroreactivity appears in patients with active CMV infection or persists in seropositive persons. A range of 8.3 to 61.6% of healthy CMV-seropositive blood donors were immunoglobulin G positive for single peptides, while 91.6% reacted to a mixture of four peptides. All convalescent-phase serum samples from 26 patients with active CMV infection reacted with either of two peptides encompassing amino acids (aa) 594 to 623 and aa 614 to 643. Patients with a primary CMV infection had patterns of reactivity to single peptides different from those of patients with reactivated CMV infection. The immunoglobulin M antibodies reacted preferentially with the peptides encompassing aa 594 to 663 of CMV pp150.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC270511 | PMC |
| http://dx.doi.org/10.1128/jcm.30.10.2735-2739.1992 | DOI Listing |
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