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Neurotoxic effects of type II-diabetes mellitus and the possible preventive effects of olive leaves supplement in male rats.
Open Vet J
October 2024
Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.
Background: Diabetes mellitus (DM) is a common metabolic disorder with well-known serious secondary complications. It is also associated with central nervous system damage. This damage is characterized by impairments in brain functions, with neurochemical and structural abnormalities.
View Article and Find Full Text PDFUnraveling Quercetin's Potential: A Comprehensive Review of Its Properties and Mechanisms of Action, in Diabetes and Obesity Complications.
Phytother Res
December 2024
Department of Food Nutrition and Safety, Dalian Medical University, Dalian, China.
Article Synopsis
- - The rising prevalence of diabetes poses a serious economic challenge globally, highlighting the need for effective treatments.
- - Plant-derived chemical substances, particularly phytochemicals from fruits and vegetables, show promise as treatments for insulin resistance and Type 2 diabetes mellitus (T2DM).
- - Quercetin, a flavonoid with multiple health benefits, has been studied for its mechanisms against diabetes and obesity-related complications, affecting various cells and demonstrating potential synergistic effects with existing diabetes medications.
Evaluation of the Hypoglycemic and Hypolipidemic Potential of Extract Fraction of Griff Seeds in Alloxan-induced Diabetic Mice.
Curr Pharm Des
October 2024
Department of Horticulture and Life Science, Yeungnam University, Gyeongsan, Republic of Korea.
Introduction: The discovery and development of new phytomedicines can be greatly aided by plants because of their tremendous therapeutic benefits, efficiency, cost-effectiveness, lack of side effects, and cheaper therapies. In this regard, , generally known as oak, is used in folkloric medicine for treating and preventing various human disorders, including diabetes.
Aim: For this purpose, the present study aimed to evaluate crude methanolic extract and various fractions of for antihyperlipidemic and antihyperglycemic potential followed by the analysis of active compounds.
Insulin combined with N-acetylcysteine attenuates type 1 diabetes-induced splenic inflammatory injury in canines by inhibiting the MAPKs-NF-κB signaling pathway and pyroptosis.
J Diabetes Complications
September 2024
College of Veterinary Medicine, South China Agricultural University, 483 Wushan road, Tianhe district, Guangzhou, 510642, People's Republic of China. Electronic address:
Purpose: Type 1 diabetes (T1DM) is a chronic metabolic disorder that can cause damage to multiple organs including the spleen. Sole insulin therapy is not satisfactory. This study aims to investigate the effects and mechanisms of combined treatment with insulin and N-acetylcysteine (NAC) on spleen damage in T1DM canines, in order to identify drugs that may better assist patients in the management of diabetes and its complications.
View Article and Find Full Text PDFInduction of Diabetes Mellitus Using Alloxan in Sprague Dawley Rats.
Cureus
June 2024
Department of Animal Health, Cheongju University, Cheongju, KOR.
Purpose: The use of rodent models for diabetes, particularly with pancreatic islet transplantation, has been prevalent in various preclinical trials. The purpose of this study is to establish a diabetes mellitus (DM) model in Sprague Dawley (SD) rats using alloxan evaluated by assessing alloxan dosage, the induction rate of diabetes, and glucose stability through insulin treatment.
Methods: Over the course of 13 experimental rounds, diabetes was induced in 86 SD rats using alloxan at concentrations of 200 mg/kg (16 rats) or 150 mg/kg (70 rats).
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