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[Advances in epigenetic regulation of the dioxygenase TET1].
Sheng Wu Gong Cheng Xue Bao
December 2024
College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Ten-eleven translocation 1 (TET1) protein is an alpha-ketoglutaric acid (α-KG) and Fe-dependent dioxygenase. It plays a role in the active demethylation of DNA by hydroxylation of 5-methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (5-hmC). Ten-eleven translocation 1 (TET1) protein is involved in maintaining genome methylation homeostasis and epigenetic regulation.
View Article and Find Full Text PDFPrecipitated-crosslinked multi-enzyme hybrid nanoflowers for efficient synthesis of α-ketoglutaric acid.
Int J Biol Macromol
January 2025
State Key Laboratory of Food Nutrition and Safety, Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, No 29, 13th, Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, PR China. Electronic address:
Cascade catalysis of glutamate oxidase (GLOX) and catalase (CAT) to perform one-pot synthetic route for α-ketoglutarate (α-KG) production offers several advantages including simplicity of operation and the generation of few reaction by-products. Nevertheless, the instability of free GLOX and CAT, the high production cost and the difficulty of recycling severely limits its industrial utilisation. Here, catalase-inorganic hybrid nanoflowers were first prepared, and cross-linked with GLOX precipitates by a macromolecular cross-linking agent dextran polyaldehyde to form a novel dual enzyme precipitation-cross-linking hybrid nanoflower (GLOX@CAT-HNFs).
View Article and Find Full Text PDFDetection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry.
Sci Rep
November 2024
Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.
Article Synopsis
- Desorption electrospray ionization (DESI) tandem mass spectrometry (MS) is utilized to determine the mutation status of isocitrate dehydrogenase (IDH) in human gliomas, which have poor surgical outcomes due to their diffuse nature.* -
- IDH mutations are clinically significant, as they correlate with better prognoses; the mutant enzyme converts alpha-ketoglutaric acid to 2-hydroxyglutarate, leading to abnormal accumulation in cells.* -
- The study evaluates two mass spectrometry methods for their effectiveness in differentiating between IDH-mutant and IDH-wildtype samples, finding that the triple quadrupole has slightly better sensitivity, which could assist in
Glutamate dehydrogenase (GDH) plays an important role in the metabolism of organisms. Its high abundance in mitochondria in particular highlights its core role in cellular physiological processes. GDH catalyzes the mutual conversion between L-glutamic acid and α-ketoglutaric acids.
View Article and Find Full Text PDFFucoidan prevents diabetic cognitive dysfunction via promoting TET2-mediated active DNA demethylation in high-fat diet induced diabetic mice.
Int J Biol Macromol
October 2024
School of Public health, Qingdao University, Qingdao, China. Electronic address:
Article Synopsis
- Diabetic cognitive dysfunction (DCD) is a problem where people with diabetes may have trouble thinking clearly, and eating more fiber could help.
- A study showed that eating more fiber was linked to better brain function in people with diabetes and in mice with similar issues.
- Fucoidan, a type of dietary fiber, was found to improve brain health by helping with important changes in DNA that can protect against DCD.
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