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Adhesion-driven vesicle translocation through membrane-covered pores.
Biophys J
January 2025
Theoretical Physics of Living Matter, Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany. Electronic address:
Translocation across barriers and through constrictions is a mechanism that is often used in vivo for transporting material between compartments. A specific example is apicomplexan parasites invading host cells through the tight junction that acts as a pore, and a similar barrier crossing is involved in drug delivery using lipid vesicles penetrating intact skin. Here, we use triangulated membranes and energy minimization to study the translocation of vesicles through pores with fixed radii.
View Article and Find Full Text PDFPredictors, patterns, and correlates of moderate-severe psychological distress among New York City College Students during Waves 2-4 of COVID-19.
Sci Rep
January 2025
Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, 622 West 168th Street, Ste. 876, New York, NY, 10032, USA.
The COVID-19 pandemic may have exacerbated mental health conditions by introducing and/or modifying stressors, particularly in university populations. We examined longitudinal patterns, time-varying predictors, and contemporaneous correlates of moderate-severe psychological distress (MS-PD) among college students. During 2020-2021, participants completed self-administered questionnaires quarterly (T1 = 562, T2 = 334, T3 = 221, and T4 = 169).
View Article and Find Full Text PDFGreen preparation of highly transparent nano-NH-UiO(Zr)-66/cellulose composite films with high-strength, superior flame retardant and UV to high-energy blue light shielding performance.
Int J Biol Macromol
January 2025
Engineering Research Center for Hemp and Product in Cold Region of Ministry of Education, School of Light Industry and Textile, Qiqihar University, Qiqihar 161006, PR China. Electronic address:
From the perspective of sustainable development and practical applications, there is a significant demand for the design of advanced cellulose-based film materials with superior mechanical, optical, and functional properties utilizing environmentally friendly strategies. Herein, biodegradable, mechanically robust and flame-retardant cellulose films with adjustable optical performance were successfully fabricated by in situ synthesis of NH-UiO(Zr)-66 via a DMF-free green process at room temperature. The results indicate that the introduction of NH-UiO(Zr)-66 enables films to realize a desirable flame retardancy (the limiting oxygen index (LOI) increased significantly from 19.
View Article and Find Full Text PDFSERS and ECL dual-mode sensing of bacterial lipopolysaccharide based on bifunctional DNA strands mediated transformation from Au@Ag nanocubes to silver nanoclusters.
J Hazard Mater
January 2025
School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma Xiang Road, Ma 'anshan, Anhui 243032, PR China. Electronic address:
Bacterial contamination is a very serious health and environmental problem, with the main source of toxicity being lipopolysaccharides in the cell walls of Gram-negative bacteria. Therefore, the development of effective analytical methods is crucial for the detection of lipopolysaccharide content. This work facilitates the efficient generation of precisely adjustable dual-mode signals for LPS detection in surface-enhanced Raman spectroscopy (SERS) and electrochemiluminescence (ECL) by inducing anisotropic morphological evolution of Au@Ag nanocubes (Au@AgNCs) through poly-cytosine (poly-C) DNA.
View Article and Find Full Text PDFDeterminants of fertility in timed artificial insemination programs in beef cattle: predictive ability and risk factors from almost 2 million data points.
Animal
December 2024
Alta Genetics Brasil Ltda., Uberaba 38055-010, Brazil.
Timed artificial insemination (TAI) is a technology widely used in cattle production based on controlling ovarian follicular growth. This study analyzed a large database aiming to determine the influence of several intrinsic and extrinsic female factors, as well as their interactions to determine risk factors and produce prediction ability in beef cattle. A total of 1 832 999 TAIs conducted on 2 002 farms across South American countries were considered for the analysis, including 15 main fixed effects or interactions in the statistical model, in addition to five random effects.
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