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Discovery of Novel Non-Nucleoside Inhibitors Interacting with Dizinc Ions of CD73.
J Med Chem
June 2024
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Article Synopsis
- High ATP levels in tumors lead to the production of adenosine, which suppresses T cells and NK cell function, creating an immunosuppressive environment detrimental to anti-tumor immunity.
- CD73 plays a key role in converting ATP to adenosine, and high CD73 levels are associated with worse cancer outcomes, making it an important target for therapy.
- A new series of non-nucleoside inhibitors have been developed to specifically target CD73, with one compound showing promise in enhancing immune response against tumors when used alongside other treatments.
Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.
Eur J Neurosci
April 2024
Department of Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
The zinc finger protein 804A (ZNF804A) and the 5'-nucleotidase cytosolic II (NT5C2) genes are amongst the first schizophrenia susceptibility genes to have been identified in large-scale genome-wide association studies. ZNF804A has been implicated in the regulation of neuronal morphology and is required for activity-dependent changes to dendritic spines. Conversely, NT5C2 has been shown to regulate 5' adenosine monophosphate-activated protein kinase activity and has been implicated in protein synthesis in human neural progenitor cells.
View Article and Find Full Text PDFZinc supplementation raises serum zinc and 5'-nucleotidase activities in healthy, USA middle-aged men.
Nutr Health
March 2023
Human Nutrition, Ohio State University, Columbus, OH, USA.
Many types of people have been noted to show less than maximum zinc functional status. One group that has not been examined is healthy middle-aged, non-vegetarian men in the USA. To determine if supplementation with zinc improves values for two plasma indicators of zinc status.
View Article and Find Full Text PDFLncRNA ZFPM2-AS1 Enhances Retinoblastoma Development by Targeting the miR-3612/NT5E Signaling Axis.
Crit Rev Eukaryot Gene Expr
August 2022
Department of Pediatrics, Wuhan Third Hospital Guanggu district, Wuhan 430074, Hubei, China.
Background - Retinoblastoma (RB) is an intraocular malignancy usually observed in children. The zinc finger protein, FOG family member 2 (ZFPM2)-antisense RNA 1 (AS1), an anomalous long non-coding RNA, is detected in many cancers. This study aimed to evaluate the role and underlying mechanism of ZFPM2-AS1 in RB.
View Article and Find Full Text PDFEffect of Maternal Marginal Zinc Deficiency on Development, Redox Status, and Gene Expression Related to Oxidation and Apoptosis in an Avian Embryo Model.
Oxid Med Cell Longev
February 2022
Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510000, China.
Maternal severe zinc (Zn) deficiency resulted in growth retardation and high mortality during embryonic development in human. Therefore, this study is aimed at evaluating the effect of maternal marginal Zn deficiency on the development and redox status to avoid severe Zn deficiency using an avian model. A total of 324 laying duck breeders at 214 days old were randomly allotted into 3 dietary Zn levels with 6 replicates of 18 ducks per replicate.
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