Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Influence of hydroxyl substitution on the inhibition of flavonoids in advanced glycation end-products formation in glucose-lysine-arginine Maillard reaction models.
Food Res Int
April 2025
School of Chemistry and Chemical Engineering, North University of China, Taiyuan 030051, China. Electronic address:
Advanced glycation end products (AGEs) generated from the Maillard reaction (MR) during food processing in the human physiological environment, have been proven to be significantly associated with various chronic metabolic diseases. In this study, 18 flavonoids were investigated to study their effects on AGEs formation during MR within a glucose-lysine-arginine model system. Five AGEs- N-carboxymethyl-lysine (CML), N-carboxyethyl-lysine (CEL), pyrraline, pentosidine, and argpyrimidine-were determined by high-performance liquid chromatography-mass spectrometry, with inhibitory rates ranging between 0 % and 71.
View Article and Find Full Text PDFEffects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment.
Metab Brain Dis
March 2025
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
The cognitive alterations observed in individuals undergoing cancer treatments have garnered more attention recently. Chemotherapy can reduce nicotinamide adenine dinucleotide (NAD+) levels by inhibiting nicotinamide phosphoribosyl transferase (NAMPT). This reduction can make cancer cells more susceptible to oxidative damage and death and may also affect non-cancerous cells, particularly the brain cells.
View Article and Find Full Text PDFLung Adenocarcinoma With Initially Co-Occurring EGFR and BRAF Double Mutation: A Case Report and Literature Review.
Thorac Cancer
March 2025
Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Vrafmurine sarcoma viral oncogene homolog B (BRAF) mutations, including both V600E and non-V600E variants, are infrequent in non-small cell lung cancer (NSCLC), representing approximately 2% of lung adenocarcinomas. Activated BRAF mutations are regarded as an underappreciated oncogenic driver in NSCLC, typically occurring in a mutually exclusive manner with epidermal growth factor receptor (EGFR) mutations, as well as ALK and ROS1 rearrangements. In recent years, advancements in multiple-gene panel testing have demonstrated that EGFR mutations and BRAF mutations can coexist.
View Article and Find Full Text PDFPhase 2 study of neoadjuvant durvalumab plus docetaxel, oxaliplatin, and S-1 with surgery and adjuvant durvalumab plus S-1 for resectable locally advanced gastric cancer.
J Immunother Cancer
March 2025
Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)
Background: Based on the phase 3 PRODIGY study, neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) have emerged as a viable treatment option for Asian patients with resectable locally advanced gastric cancer (LAGC). This phase 2 study evaluated the efficacy and safety of combining neoadjuvant durvalumab with DOS, followed by surgery and adjuvant durvalumab plus S-1 chemotherapy, for resectable LAGC.
Methods: Patients with LAGC with cT2/3N+or cT4Nany tumors were enrolled in this study.
8-Ethynyl-2'-deoxyisoguanosine with two tautomeric forms in the unit cell: crystal structure, packing and Hirshfeld surface analysis.
Acta Crystallogr C Struct Chem
April 2025
Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstrasse 11, 48149 Münster, Germany.
Isoguanine nucleosides constructed by different heterocyclic skeletons play a significant role in the context of genetic code expansion, as well as for purine-purine base pairing. However, with respect to structure analysis, only limited information is available on this class of nucleosides. In this study, the single-crystal X-ray structure of 8-ethynyl-2'-deoxyisoguanosine, CHNO·CHNO·2HO (1), has been investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!