This rare mycosis is caused by Paracoccidiodis loboii and is found mainly among indians of the Amazon forest. It is a cutaneous disease. No visceral affection was ever described, though generalized skin disease has been reported. One case of cheloid paracoccidioidomycosis was studied with gallium-67. The radiopharmaceutical has accumulated in the affected area and in a lymph node, although adenomegaly be rare. Degree of accumulation was discrete/moderate but the patient had been under irregular treatment for 10 years. As no laboratorial data are evaluable for this affection, gallium-67 may represent a means of disease extent and therapy efficacy evaluation.
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Microorganisms
September 2023
The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by . Serological cross-reactions among highly pathogenic fungal infections and related diseases have been reported. However, the true cross-reaction of antibodies against has remained unknown due to the use of positive control sera from infected dolphins.
View Article and Find Full Text PDFMycopathologia
April 2023
Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, 04023062, Brazil.
Paracoccidioidomycosis (PCM) defines a broad spectrum of human and animal diseases caused by Paracoccidioides species (Onygenales). In the twenty-first century, Paracoccidioides advanced from a monotypic taxon to a genus that harbors seven species, including P. brasiliensis sensu stricto, P.
View Article and Find Full Text PDFClin Dermatol
October 2012
Faculty of Medicine, Nilton Liins University, Av. Professor Nilton Lins 3259, Parque das Laranjeiras, Manaus, Amazonas, Brazil.
Lobomycosis is a rare chronic fungal infection of the subcutaneous tissue found in South America, mainly in Brazil. It is caused by Lacazia loboi. Its clinical manifestations are dermal nodules, either lenticular or in plaques, and keloidlike lesions that can resemble nodular leprosy or leishmaniasis, other subcutaneous mycoses (sporotrychosis, chromomycosis, paracoccidioidomycosis), keloids, and malignant tumors.
View Article and Find Full Text PDFHum Pathol
February 2008
Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém-PA 66055-240, Brazil.
Jorge Lobo's disease, or lacaziosis, is a chronic deep mycosis that clinically manifests as solid, variable-sized nodular parakeloidal lesions. Few studies have characterized the in situ cellular and humoral immune response, especially the involvement of cytokines with immunosuppressive effects such as TGF-beta. The objective this paper was to analyze the expression of TGF-beta in cutaneous lesions in lacaziosis and investigate its importance in the etiopathogy of the disease.
View Article and Find Full Text PDFInt J Dermatol
February 2007
Laboratorio de Estudio de Antígenos, Instituto de Biomedicina, Universidad Central de Venezuela/Ministerio de Salud y Desarrollo Social, Caracas, Venezuela.
Lobomycosis is a chronic dermal infection that presents a wide spectrum of clinical- dermatological manifestations, mainly characterized by the development of keloid lesions as well as nodular, verrucoid and sometimes ulcerous forms. The etiological agent at an international level, according to the consensus nomenclature, has been called Loboa loboi, even though recently it has been accommodated as Lacazia loboi. The present review extensively covers the clinical-epidemiological aspects as well as the most outstanding historical aspects, including the Venezuelan experience and the presentation of two new cases, which substantiate the Amazon basin as an endemic area for the disease.
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