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Food Confusion Between Edible and Poisonous Plants: A 22-Year Retrospective of the Southeastern France Poison Control Center.
Toxins (Basel)
December 2024
Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Hôpital Sainte Marguerite, Clinical Pharmacology and Poison Control Centre, 13274 Marseille, France.
Objective: In some regions of the globe, accidental food confusion regarding plants can cause severe poisoning events and deaths. The aim of this study was to report on those confusions from the Marseille Poison Control Centre's (PCC) experience from 2002 to 2023.
Results: Over 22 years, 2197 food confusion events were managed with 321 different species.
Protective efficacy of extract on spermatogenesis in streptozotocin-induced diabetic rats.
Zygote
April 2024
Department of Anatomical Sciences, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran.
Men with diabetes frequently experience spermatogenic dysfunction, which is the most significant sign that diabetes has harmed their ability to reproduce. The effect of various doses of the hydro-alcoholic extract of leaves on the pituitary-gonadal axis, sperm motility and number, antioxidant system, changes in testicular tissue structure, and spermatogenesis in healthy and diabetic rats has been examined in the current study. Eighty male rats that had been streptozotocin-induced diabetic and healthy were divided into eight groups: (1) control, (2) (50 mg/kg), (3) (100 mg/kg), (4) (200 mg/kg), (5) DM (6) DM+ (50 mg/kg), (7) DM+ (100 mg/kg) and (8) DM+ (200 mg/kg) and were administered orally for 48 days consecutive.
View Article and Find Full Text PDFDeliberate Self-Poisoning with Plants in Southeastern France, a Poison Center 20-Year Report.
Toxins (Basel)
November 2023
Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Hôpital Sainte Marguerite, Clinical Pharmacology and Poison Control Centre, 13009 Marseille, France.
Article Synopsis
- * The majority of poisonings (71%) stemmed from a predominant native species, and only four fatalities were reported, with most patients experiencing mild to moderate symptoms.
- * The study highlights the need for a specific treatment protocol due to a lack of standardized care, noting that only a small number of patients required antidotes such as Digifab or physostigmine.
Oleander-Associated Keratitis and Uveitis.
Cornea
October 2022
Department of Ophthalmology, Mayo Clinic, Rochester, MN.
Purpose: Oleander is a poisonous plant with extensively documented systemic side effects; however, oleander's ophthalmic side effects have not been detailed in the literature. We report a case of oleander-associated keratitis with subsequent corneal edema and anterior uveitis.
Methods: This is a case report and review of relevant literature.
Targeted Osmotic Lysis: A Novel Approach to Targeted Cancer Therapies.
Biomedicines
April 2022
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
The conventional treatment of cancer has been based on the delivery of non-selective toxins and/or ionizing energy that affect both the cancer and normal tissues in the hope of destroying the offending disease before killing the patient. Unfortunately, resistance often develops to these treatments and patients experience severe, dose-limiting adverse effects that reduce treatment efficacy and compromise quality of life. Recent advances in our knowledge of the biology of tumor cells and their microenvironment, the recognition of surface proteins that are unique to specific cancers and essential to cell growth and survival and signaling pathways associate with invasion and metastasis have led to the development of targeted therapies that are able to identify specific cellular markers and more selectively deliver lethal treatment to the invading cancer thus improving efficacy and limiting adverse effects.
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