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Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review.
J Am Acad Dermatol
April 2019
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:
Background: This systematic review assesses effects of paternal exposure to dermatologic medications by using the former US Food and Drug Administration (FDA) pregnancy categories as a benchmark.
Objective: To assess whether systemic dermatologic medications can cause infertility and teratogenicity when taken by men.
Methods: Categories D and X dermatologic medications were identified; a systematic review of the literature and reviews of the FDA Adverse Events Reporting System and prescribing information were performed to identify the effects of these medications on male fertility and teratogenicity.
Analysis of the cytoskeleton organization and its possible functions in male earthworm germ-line cysts equipped with a cytophore.
Cell Tissue Res
October 2016
Department of Animal Histology and Embryology, University of Silesia, Bankowa 9, 40-007, Katowice, Poland.
We studied the organization of F-actin and the microtubular cytoskeleton in male germ-line cysts in the seminal vesicles of the earthworm Dendrobaena veneta using light, fluorescent and electron microscopy along with both chemically fixed tissue and life cell imaging. Additionally, in order to follow the functioning of the cytoskeleton, we incubated the cysts in colchicine, nocodazole, cytochalasin D and latrunculin A. The male germ-line cells of D.
View Article and Find Full Text PDFThiocolchicoside has long been used as a muscle relaxant, despite a lack of proven efficacy beyond the placebo effect. Its chemical structure consists of colchicine, a sugar (ose) and a sulphur-containing radical (thio), and its adverse effects are therefore likely to be similar to those of colchicine. Using the standard Prescrire methodology, we reviewed the available data on the adverse effects of thiocolchicoside.
View Article and Find Full Text PDF[A fast method for preparing the mouse germ cell slides].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
February 2014
Center for Experimental Medicine Research, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objective: To establish a new method of fast preparation of mouse germ cell slides for immunofluorescence assay.
Methods: Mice of different developing stages (at postnatal days 16, 21, 28 and 120) were treated with colchicine by intraperitoneal injection respectively, and 3 hours later, the testes were taken out and the tunica albuginea were removed. The seminiferous tubules were separated and minced into small pieces, resuspended with ice-cold PBS, and the cells were filtered and collected by centrifugation.
Most regions of mouse epididymis are able to phagocytose immature germ cells.
Reproduction
May 2014
Department of Animal Reproduction, INIA, Avenida Puerta de Hierro 12, Local 10, Madrid 28040, Spain.
The role of the epididymis as a quality control organ in preventing infertile gametes entering the ejaculate has been extensively explored, and it has been suggested that a specific region of mammalian epididymis is able to phagocytose abnormal germ cells. This study examines whether the epithelium of certain zones of the mouse epididymis can act as a selection barrier by removing immature germ cells from the lumen by phagocytosis. To detect the presence of immature germ cells in the epididymis, we generated transgenic mice expressing enhanced green fluorescent protein under the deleted in azoospermia-like (mDazl) promoter to easily identify immature germ cells under fluorescence microscopy.
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