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A Transition From Interindividual Uniformity to Diversity in Appearance and Transcriptional Features at Midlife in Caenorhabditis elegans.
Genes Cells
January 2025
Laboratory for Molecular Biology of Aging, RIKEN Center for Biosystems Dynamics Research (BDR), Hyogo, Japan.
During embryogenesis, organisms function as a robust system that ensures uniformity within individuals, but they lose robustness and develop variations at advanced ages. However, when and how organisms lose this robustness remains largely elusive. Here, we identified a sharp transition from interindividual uniformity to diversity in the appearance and transcriptional features of age-matched Caenorhabditis elegans in midlife.
View Article and Find Full Text PDFGenome-modified Caenorhabditis elegans expressing the human cytochrome P450 (CYP1A1 and CYP1A2) pathway: An experimental model for environmental carcinogenesis and pharmacological research.
Environ Int
December 2024
Department of Analytical, Environmental and Forensic Sciences, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address:
Article Synopsis
- Polycyclic aromatic hydrocarbons (PAHs), like benzo[a]pyrene (BaP), arise from incomplete combustion and are found in sources like tobacco smoke and charbroiled food, posing cancer risks.
- Researchers genetically modified the nematode Caenorhabditis elegans to include human CYP1A1, CYP1A2, and epoxide hydrolase to study the effects of BaP exposure, observing changes in behavior and reproductive performance, such as increased pharyngeal pumping and decreased brood size.
- The findings revealed that the humanized worms experienced more severe reproductive toxicity and genetic mutations when exposed to BaP, highlighting the potential of these modified organisms for improving research practices while working towards the
The role of Sod-2 in different types of neuronal damage and behavioral changes induced by polystyrene nanoplastics in Caenorhabditis elegans.
Ecotoxicol Environ Saf
December 2024
Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province 350122, China; Fujian Provincial Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, China. Electronic address:
Article Synopsis
- Polystyrene nanoplastics (PS-NPs) are harmful substances that accumulate in organisms and cause neurotoxicity, although the specific mechanisms behind this toxicity are not well understood.
- In a study using nematodes, researchers found that PS-NPs lead to behavioral damage and harm to specific types of neurons, with significant reductions in neurotransmitter levels observed.
- The study identified that PS-NPs increase reactive oxygen species (ROS) production and decrease the Sod-2 protein, and showed that using the mitochondrial ROS scavenger Mitoquinone can help reduce these toxic effects.
Elucidating the effective age for dietary restriction and the key metabolites involved.
Exp Gerontol
November 2024
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, Malaysia. Electronic address:
Dietary restriction (DR) extends lifespan in various species, but its effect at different ages, especially when started later, is unclear. This study used Caenorhabditis elegans to explore the impact of DR at different ages. Worms were divided into control and DR groups, with daily survival monitored.
View Article and Find Full Text PDFNisin A elevates adenosine to achieve anti-inflammatory activity.
Food Funct
October 2024
School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, Zhejiang, People's Republic of China.
Article Synopsis
- Inflammation is a common physiological condition linked to many diseases, with current anti-inflammatory drugs often causing side effects such as nausea, pain, and organ dysfunction.
- Research is now focused on natural compounds for anti-inflammatory treatment, with nisin, a bioactive peptide, showing promise for its anti-inflammatory and antibacterial properties.
- This study demonstrates nisin A's direct anti-inflammatory effects and reveals its role in regulating adenosine and altering specific signaling pathways, paving the way for future anti-inflammatory strategies using nisin A.
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